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ALM201

Chemical Structure : ALM201

CAS No.: 959961-27-4

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ALM201 (ALM-201)

Catalog No.: PC-38698Not For Human Use, Lab Use Only.

ALM201 is a small 23 amino acid peptide derived from the FK506 binding protein FKBPL, a targeted microtubule binding agent which exhibits potent anti-angiogenic activity in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ALM201 is a small 23 amino acid peptide derived from the FK506 binding protein FKBPL, a targeted microtubule binding agent which exhibits potent anti-angiogenic activity in vitro and in vivo.
    ALM201 inhibits endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4.
    ALM201 reduced CSCs in ovarian cancer cell lines and primary samples by inducing differentiation.

    Physicochemical Properties

    M.Wt 2575.819
    Formula C110H179N31O40
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    IRQQPRDPPTETLELEVSPDPAS, Ile-Arg-Gln-Gln-Pro-Arg-Asp-Pro-Pro-Thr-Glu-Thr-Leu-Glu-Leu-Glu-Val-Ser-Pro-Asp-Pro-Ala-Ser

    References

    1. Martin O'Rourke, et al. Cancer Res (2011) 71 (8_Supplement): 3288.

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