| Cat. No. |
Product Name |
Information |
| PC-42619 |
Lexibulin
Tubulin inhibitor
|
Lexibulin (CYT997) is an orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo. |
| PC-45982 |
Cephalomannine
Microtubule stabilizer
|
Cephalomannine is taxol derivative with antitumor, antiproliferative properties, is active in promoting microtubule assembly. |
| PC-42466 |
Ixabepilone
Microtubule stabilizer, TUBB3 inhibitor
|
Ixabepilone (Azaepothilone B, BMS-247550) is a semisynthetic Epothilone B analogue and potent, orally active microtubule stabilizer, also is a TUBB3 inhibitor. |
| PC-45256 |
4-Demethylepipodophyllotoxin
Microtubule inhibitor
|
4'-Demethylepipodophyllotoxin (4'-DMEP) is a potent inhibitor of microtubule assembly, and a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer compounds. |
| PC-45268 |
Fosbretabulin disodium
Microtubule inhibitor
|
Fosbretabulin disodium (CA4DP, Combretastatin A-4) is a derivative of combretastatin that acts as a microtubule destabilising agent, damages the vasculature (blood vessels) of cancer tumours causing central necrosis. |
| PC-45239 |
Vinblastine
Microtubule inhibitor
|
Vinblastine is a cytotoxic alkaloid that binds tubulin and inhibits the assembly of microtubules, a chemotherapy agent for treatment of a number of types of cancer. |
| PC-45151 |
Epothilone B
Microtubule stabilizer
|
Epothilone B (EPO-906, Patupilone) blood-brain barrier-permeable microtubule-stabilizing agent that promotes tubulin polymerization and induces G2-M cell cycle arrest with EC50 of 32 nM in HeLa cells. |
| PC-24654 |
RGN6024
Tubulin destabilizer
|
RGN6024 is a brain-penetrant, small molecule tubulin destabilizer, binds the colchicine binding site of tubulin, displays high potency against GB cell lines. |
| PC-24416 |
Tubulin inhibitor No.07
Tubulin inhibitor
|
Tubulin inhibitor No.07 is a novel tubulin inhibitor, irectly binds to tubulin dimers and interferes with microtubule polymerization, shows anti-cancer and anti-metastatic effects in colon cancer and tumoroids (Hela cell IC50=455 nM). |
| PC-24239 |
IMB5046
Microtubule inhibitor
|
IMB5046 is a novel nitrobenzoate microtubule inhibitor, inhibits tubulin polymerization and shows cytotoxicity against multidrug-resistant cell lines in vitro and in vivo. |
| PC-24204 |
TUBG1 inhibitor L12
γ-tubulin1 inhibitor
|
TUBG1 inhibitor L12 is a specific inhibitor of γ-tubulin1 (TUBG1) and γ-tubule polymerizing agent, selectively inhibits TUBG1 activity in RB1-deficient tumor cells without affecting TUBG2. |
| PC-24203 |
Citral dimethyl acetal
γ-tubulin inhibitor
|
Citral dimethyl acetal (CDA) is a specific inhibitor of γ-tubulin, specifically inhibits the nuclear activity of γ-tubulin without affecting microtubules dynamics, increases E2F activity without affecting microtubules. |
