| Cat. No. |
Product Name |
Information |
| PC-45268 |
Fosbretabulin disodium
Microtubule inhibitor
|
Fosbretabulin disodium (CA4DP, Combretastatin A-4) is a derivative of combretastatin that acts as a microtubule destabilising agent, damages the vasculature (blood vessels) of cancer tumours causing central necrosis. |
| PC-45239 |
Vinblastine
Microtubule inhibitor
|
Vinblastine is a cytotoxic alkaloid that binds tubulin and inhibits the assembly of microtubules, a chemotherapy agent for treatment of a number of types of cancer. |
| PC-45151 |
Epothilone B
Microtubule stabilizer
|
Epothilone B (EPO-906, Patupilone) blood-brain barrier-permeable microtubule-stabilizing agent that promotes tubulin polymerization and induces G2-M cell cycle arrest with EC50 of 32 nM in HeLa cells. |
| PC-23753 |
C118P
Microtubule inhibitor
|
C118P is a phosphate prodrug of C118, which is a novel microtubule protein inhibitor, exhibits good inhibitory activities against ovarian cancer and lung cancer. |
| PC-23660 |
CAIS-2
Chromosome congression inhibitor
|
CAIS-2 is a specific mitotic inhibitor, selectively inhibits chromosome congression without affecting spindle microtubules. |
| PC-23659 |
CAIS-1
Chromosome congression inhibitor
|
CAIS-1 is a small molecule inhibitor of chromosome congression, inhibits chromosome congression at low concentrations and spindle microtubule formation at high concentrations. |
| PC-23630 |
OXi8006
Tubulin inhibitor
|
OXi8006 is a small molecule vascular disrupting agent and tubulin binding inhibior, inhibits tubulin assembly (IC50=1.1 uM) and shows cytotoxicity with GI50 of 3.45 nM against SK-OV-3 cells. |
| PC-23470 |
Gatorbulin-1
Tubulin inhibitor
|
Gatorbulin-1 (GB1) is a microtubule-destabilizing cyclodepsipeptide, directly inhibits tubulin polymerization in vitro in an iron-independent manner. |
| PC-23206 |
Lisavanbulin dihydrochloride
Tubulin inhibitor
|
Lisavanbulin dihydrochloride (BAL101553) is a microtubule-destabilizing drug, binds to the colchicine site of tubulin, is the prodrug of the microtubule targeting agent Avanbulin (BAL27862). |
| PC-23205 |
Lisavanbulin
Tubulin inhibitor
|
Lisavanbulin (BAL101553) is a microtubule-destabilizing drug, binds to the colchicine site of tubulin, is the prodrug of the microtubule targeting agent Avanbulin (BAL27862). |
| PC-23110 |
BNZ-111
Tubulin inhibitor
|
BNZ-111 is a novel reversible tubulin inhibitor, binds the β subunit of curved tubulin, possesses potent anticancer activities to various cancer cell lines. |
| PC-22895 |
MI-181
M-phase inhibitor
|
MI-181 (Mitotic inhibitor-181) is a potent M-phase inhibitor with mitotic arrest IC50 of 23 nM and cell death IC50 of 17 nM, inhibits tubulin polymerization and modulates cilia length and biogenesis. |
