| Cat. No. |
Product Name |
Information |
| PC-45268 |
Fosbretabulin disodium
Microtubule inhibitor
|
Fosbretabulin disodium (CA4DP, Combretastatin A-4) is a derivative of combretastatin that acts as a microtubule destabilising agent, damages the vasculature (blood vessels) of cancer tumours causing central necrosis. |
| PC-45239 |
Vinblastine
Microtubule inhibitor
|
Vinblastine is a cytotoxic alkaloid that binds tubulin and inhibits the assembly of microtubules, a chemotherapy agent for treatment of a number of types of cancer. |
| PC-45151 |
Epothilone B
Microtubule stabilizer
|
Epothilone B (EPO-906, Patupilone) blood-brain barrier-permeable microtubule-stabilizing agent that promotes tubulin polymerization and induces G2-M cell cycle arrest with EC50 of 32 nM in HeLa cells. |
| PC-24239 |
IMB5046
Microtubule inhibitor
|
IMB5046 is a novel nitrobenzoate microtubule inhibitor, inhibits tubulin polymerization and shows cytotoxicity against multidrug-resistant cell lines in vitro and in vivo. |
| PC-24204 |
TUBG1 inhibitor L12
γ-tubulin1 inhibitor
|
TUBG1 inhibitor L12 is a specific inhibitor of γ-tubulin1 (TUBG1) and γ-tubule polymerizing agent, selectively inhibits TUBG1 activity in RB1-deficient tumor cells without affecting TUBG2. |
| PC-24203 |
Citral dimethyl acetal
γ-tubulin inhibitor
|
Citral dimethyl acetal (CDA) is a specific inhibitor of γ-tubulin, specifically inhibits the nuclear activity of γ-tubulin without affecting microtubules dynamics, increases E2F activity without affecting microtubules. |
| PC-24202 |
Citral
γ-tubulin inhibitor
|
Citral is a natural ALDH1A inhibitor, also is a small molecule inhibitor of nuclear γ-tubulin, affects the transcriptional activity of E2F and the protein levels of RB1. |
| PC-23848 |
Epothilone D
Microtubule stabilizer
|
Epothilone D (KOS 862) is a potent microtubule stabilizer, inhibits CCRF-CEM/VBL1000 cells (2,048-fold resistance to vinblastine) with IC50 of 2.9 nM. |
| PC-23753 |
C118P
Microtubule inhibitor
|
C118P is a phosphate prodrug of C118, which is a novel microtubule protein inhibitor, exhibits good inhibitory activities against ovarian cancer and lung cancer. |
| PC-23660 |
CAIS-2
Chromosome congression inhibitor
|
CAIS-2 is a specific mitotic inhibitor, selectively inhibits chromosome congression without affecting spindle microtubules. |
| PC-23659 |
CAIS-1
Chromosome congression inhibitor
|
CAIS-1 is a small molecule inhibitor of chromosome congression, inhibits chromosome congression at low concentrations and spindle microtubule formation at high concentrations. |
| PC-23630 |
OXi8006
Tubulin inhibitor
|
OXi8006 is a small molecule vascular disrupting agent and tubulin binding inhibior, inhibits tubulin assembly (IC50=1.1 uM) and shows cytotoxicity with GI50 of 3.45 nM against SK-OV-3 cells. |
