| Cat. No. |
Product Name |
Information |
| PC-45982 |
Cephalomannine
Microtubule stabilizer
|
Cephalomannine is taxol derivative with antitumor, antiproliferative properties, is active in promoting microtubule assembly. |
| PC-42466 |
Ixabepilone
Microtubule stabilizer, TUBB3 inhibitor
|
Ixabepilone (Azaepothilone B, BMS-247550) is a semisynthetic Epothilone B analogue and potent, orally active microtubule stabilizer, also is a TUBB3 inhibitor. |
| PC-45256 |
4-Demethylepipodophyllotoxin
Microtubule inhibitor
|
4'-Demethylepipodophyllotoxin (4'-DMEP) is a potent inhibitor of microtubule assembly, and a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer compounds. |
| PC-45268 |
Fosbretabulin disodium
Microtubule inhibitor
|
Fosbretabulin disodium (CA4DP, Combretastatin A-4) is a derivative of combretastatin that acts as a microtubule destabilising agent, damages the vasculature (blood vessels) of cancer tumours causing central necrosis. |
| PC-45239 |
Vinblastine
Microtubule inhibitor
|
Vinblastine is a cytotoxic alkaloid that binds tubulin and inhibits the assembly of microtubules, a chemotherapy agent for treatment of a number of types of cancer. |
| PC-45151 |
Epothilone B
Microtubule stabilizer
|
Epothilone B (EPO-906, Patupilone) blood-brain barrier-permeable microtubule-stabilizing agent that promotes tubulin polymerization and induces G2-M cell cycle arrest with EC50 of 32 nM in HeLa cells. |
| PC-25515 |
OXi8007
Tubulin inhibitor
|
OXi8007 is a vascular disrupting agent and watersoluble phosphate prodrug of OXi8006, inhibits tubulin assembly with IC50 of 1.1 uM, shows cytotoxic against DU-145 cells with GI50 of 36 nM. |
| PC-25514 |
KGP265
Tubulin inhibitor
|
KGP265 is a water-soluble phosphate prodrug salt of benzosuberene-based tubulin-binding agent KGP18. |
| PC-25513 |
OXi6197
Tubulin inhibitor
|
OXi6197 (KGP04) is the phosphate prodrug of OXi6196, which is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization, rapidly releases OXi6196 in the presence of alkaline phosphatase. |
| PC-25512 |
OXi6196
Tubulin inhibitor
|
OXi6196 is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization utilizing a cell-free assay. |
| PC-25427 |
VASH1-VASH2 inibitor LV87
VASH1/2 inhibitor
|
LV87 is a potent, selective and covalent inhibitor of tubulin detyrosinating enzymes VASH1 and VASH2 with IC50 of 0.01 and 0.06 uM respectively, inhibits tubulin detyrosination. |
| PC-25361 |
Tubulin inhibitor 89
Tubulin inhibitor
|
Tubulin inhibitor 89 is a novel potent colchicine-site inhibitor of tubulin, has significant cytostatic activity against human Hela (cervical) and HCT116 (colonic) tumor cells with IC50 of 1.13 and 0.65 uM respectively, interferes with the assembly of microtubules by inhibiting PI3K/Akt signaling pathway. |
