| Cat. No. |
Product Name |
Information |
| PC-42619 |
Lexibulin
Tubulin inhibitor
|
Lexibulin (CYT997) is an orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo. |
| PC-45982 |
Cephalomannine
Microtubule stabilizer
|
Cephalomannine is taxol derivative with antitumor, antiproliferative properties, is active in promoting microtubule assembly. |
| PC-42466 |
Ixabepilone
Microtubule stabilizer, TUBB3 inhibitor
|
Ixabepilone (Azaepothilone B, BMS-247550) is a semisynthetic Epothilone B analogue and potent, orally active microtubule stabilizer, also is a TUBB3 inhibitor. |
| PC-45256 |
4-Demethylepipodophyllotoxin
Microtubule inhibitor
|
4'-Demethylepipodophyllotoxin (4'-DMEP) is a potent inhibitor of microtubule assembly, and a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer compounds. |
| PC-45268 |
Fosbretabulin disodium
Microtubule inhibitor
|
Fosbretabulin disodium (CA4DP, Combretastatin A-4) is a derivative of combretastatin that acts as a microtubule destabilising agent, damages the vasculature (blood vessels) of cancer tumours causing central necrosis. |
| PC-45239 |
Vinblastine
Microtubule inhibitor
|
Vinblastine is a cytotoxic alkaloid that binds tubulin and inhibits the assembly of microtubules, a chemotherapy agent for treatment of a number of types of cancer. |
| PC-45151 |
Epothilone B
Microtubule stabilizer
|
Epothilone B (EPO-906, Patupilone) blood-brain barrier-permeable microtubule-stabilizing agent that promotes tubulin polymerization and induces G2-M cell cycle arrest with EC50 of 32 nM in HeLa cells. |
| PC-25515 |
OXi8007
Tubulin inhibitor
|
OXi8007 is a vascular disrupting agent and watersoluble phosphate prodrug of OXi8006, inhibits tubulin assembly with IC50 of 1.1 uM, shows cytotoxic against DU-145 cells with GI50 of 36 nM. |
| PC-25514 |
KGP265
Tubulin inhibitor
|
KGP265 is a water-soluble phosphate prodrug salt of benzosuberene-based tubulin-binding agent KGP18. |
| PC-25513 |
OXi6197
Tubulin inhibitor
|
OXi6197 (KGP04) is the phosphate prodrug of OXi6196, which is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization, rapidly releases OXi6196 in the presence of alkaline phosphatase. |
| PC-25512 |
OXi6196
Tubulin inhibitor
|
OXi6196 is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization utilizing a cell-free assay. |
| PC-25427 |
VASH1-VASH2 inibitor LV87
VASH1/2 inhibitor
|
LV87 is a potent, selective and covalent inhibitor of tubulin detyrosinating enzymes VASH1 and VASH2 with IC50 of 0.01 and 0.06 uM respectively, inhibits tubulin detyrosination. |
