| Cat. No. |
Product Name |
Information |
| PC-45982 |
Cephalomannine
Microtubule stabilizer
|
Cephalomannine is taxol derivative with antitumor, antiproliferative properties, is active in promoting microtubule assembly. |
| PC-42466 |
Ixabepilone
Microtubule stabilizer, TUBB3 inhibitor
|
Ixabepilone (Azaepothilone B, BMS-247550) is a semisynthetic Epothilone B analogue and potent, orally active microtubule stabilizer, also is a TUBB3 inhibitor. |
| PC-45256 |
4-Demethylepipodophyllotoxin
Microtubule inhibitor
|
4'-Demethylepipodophyllotoxin (4'-DMEP) is a potent inhibitor of microtubule assembly, and a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer compounds. |
| PC-45268 |
Fosbretabulin disodium
Microtubule inhibitor
|
Fosbretabulin disodium (CA4DP, Combretastatin A-4) is a derivative of combretastatin that acts as a microtubule destabilising agent, damages the vasculature (blood vessels) of cancer tumours causing central necrosis. |
| PC-45239 |
Vinblastine
Microtubule inhibitor
|
Vinblastine is a cytotoxic alkaloid that binds tubulin and inhibits the assembly of microtubules, a chemotherapy agent for treatment of a number of types of cancer. |
| PC-45151 |
Epothilone B
Microtubule stabilizer
|
Epothilone B (EPO-906, Patupilone) blood-brain barrier-permeable microtubule-stabilizing agent that promotes tubulin polymerization and induces G2-M cell cycle arrest with EC50 of 32 nM in HeLa cells. |
| PC-25945 |
SP-1-39
Tubulin inhibitor
|
SP-1-39 is a novel colchicine-binding site inhibitor (CBSI), inhibits tubulin-polymerization, exhibits high cytotoxic activity in vitro with IC50 of 0.2 nM (PC-3/TxR). |
| PC-25919 |
Verubulin
Tubulin inhibitor
|
Verubulin (MPC-6827) is a microtubule-destabilizing agent and microtubule formation inhibitor, effectively inhibits the polymerization of tubulin in vitro, inhibits cancer cell lines regardless of the expression levels of the multidrug resistance ABC transporters MDR-1 (Pgp-1), MRP-1, and BCRP-1. |
| PC-25918 |
SB-216
Tubulin inhibitor
|
SB-216 is a potent and brain-penetrable tubulin inhibitor, inhibits cell growth and migration, and induces apoptosis with low nanomolar potencies in breast cancer brain metastasis (BCBM) models. |
| PC-25515 |
OXi8007
Tubulin inhibitor
|
OXi8007 is a vascular disrupting agent and watersoluble phosphate prodrug of OXi8006, inhibits tubulin assembly with IC50 of 1.1 uM, shows cytotoxic against DU-145 cells with GI50 of 36 nM. |
| PC-25514 |
KGP265
Tubulin inhibitor
|
KGP265 is a water-soluble phosphate prodrug salt of benzosuberene-based tubulin-binding agent KGP18. |
| PC-25513 |
OXi6197
Tubulin inhibitor
|
OXi6197 (KGP04) is the phosphate prodrug of OXi6196, which is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization, rapidly releases OXi6196 in the presence of alkaline phosphatase. |
