Ixabepilone | Microtubule stabilizer, TUBB3 inhibitor

Chemical Structure : Ixabepilone

CAS No.: 219989-84-1

Ixabepilone (Azaepothilone B, BMS-247550)

Catalog No.: PC-42466Not For Human Use, Lab Use Only.

Ixabepilone (Azaepothilone B, BMS-247550) is a semisynthetic Epothilone B analogue and potent, orally active microtubule stabilizer, also is a TUBB3 inhibitor.

Packing	Price	Stock
5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$358	In stock
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Biological Activity

Ixabepilone (Azaepothilone B, BMS-247550) is a semisynthetic Epothilone B analogue and potent, orally active microtubule stabilizer, also is a TUBB3 inhibitor.
Ixabepilone shows a broad spectrum of activity against a panel of tumor cell lines in vitro (IC50=1.4-34.5 nM).
Ixabepilone retains the antineoplastic activity against human cancers that are resistance to paclitaxel both in vitro and in vivo.

Physicochemical Properties

M.Wt	506.6978
Formula	C27H42N2O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	17-Oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (1S,3S,7S,10R,11S,12S,16R)-

References

1. Lee FY, et al. Clin Cancer Res. 2001 May;7(5):1429-37.

2. Yamaguchi H, et al. Cancer Res. 2002 Jan 15;62(2):466-71.

3. Peterson JK, et al. Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6950-8.

Ixabepilone (Azaepothilone B, BMS-247550)

Biological Activity

Physicochemical Properties

References

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