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Chemical Structure : Ixabepilone
CAS No.: 219989-84-1
Catalog No.: PC-42466Not For Human Use, Lab Use Only.
Ixabepilone (Azaepothilone B, BMS-247550) is a semisynthetic Epothilone B analogue and potent, orally active microtubule stabilizer.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Ixabepilone (Azaepothilone B, BMS-247550) is a semisynthetic Epothilone B analogue and potent, orally active microtubule stabilizer.
Ixabepilone shows a broad spectrum of activity against a panel of tumor cell lines in vitro (IC50=1.4-34.5 nM).
Ixabepilone retains the antineoplastic activity against human cancers that are resistance to paclitaxel both in vitro and in vivo.
| M.Wt | 506.6978 | |
| Formula | C27H42N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
17-Oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (1S,3S,7S,10R,11S,12S,16R)- |
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1. Lee FY, et al. Clin Cancer Res. 2001 May;7(5):1429-37.
2. Yamaguchi H, et al. Cancer Res. 2002 Jan 15;62(2):466-71.
3. Peterson JK, et al. Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6950-8.
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