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Chemical Structure : Epothilone B
CAS No.: 152044-54-7
Catalog No.: PC-45151Not For Human Use, Lab Use Only.
Epothilone B (EPO-906, Patupilone) blood-brain barrier-permeable microtubule-stabilizing agent that promotes tubulin polymerization and induces G2-M cell cycle arrest with EC50 of 32 nM in HeLa cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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Epothilone B (EPO-906, Patupilone) blood-brain barrier-permeable microtubule-stabilizing agent that promotes tubulin polymerization and induces G2-M cell cycle arrest with EC50 of 32 nM in HeLa cells.
Epothilone B exhibits potent cytotoxicity in MCF-7 and A549 cells (EC50=0.3 and 2.7 nM respectively), and inhibits growth of HCT-15 tumors in mice in vivo.
Epothilone B decreases scarring after rodent spinal cord injury by abrogating polarization and directed migration of scar-forming fibroblasts.
| M.Wt | 507.6825 | |
| Formula | C27H41NO6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (1S,3S,7S,10R,11S,12S,16R)- |
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1. Narvi E, et al. Br J Cancer. 2013 Jan 15;108(1):82-90.
2. Ruschel J, et al. Science. 2015 Apr 17;348(6232):347-52.
3. O'Reilly T, et al. Cancer Chemother Pharmacol. 2008 Nov;62(6):1045-54.
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