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Epothilone B

Chemical Structure : Epothilone B

CAS No.: 152044-54-7

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Epothilone B (EPO-906, Patupilone)

Catalog No.: PC-45151Not For Human Use, Lab Use Only.

Epothilone B (EPO-906, Patupilone) blood-brain barrier-permeable microtubule-stabilizing agent that promotes tubulin polymerization and induces G2-M cell cycle arrest with EC50 of 32 nM in HeLa cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Epothilone B (EPO-906, Patupilone) blood-brain barrier-permeable microtubule-stabilizing agent that promotes tubulin polymerization and induces G2-M cell cycle arrest with EC50 of 32 nM in HeLa cells.
Epothilone B exhibits potent cytotoxicity in MCF-7 and A549 cells (EC50=0.3 and 2.7 nM respectively), and inhibits growth of HCT-15 tumors in mice in vivo.
Epothilone B decreases scarring after rodent spinal cord injury by abrogating polarization and directed migration of scar-forming fibroblasts.

Physicochemical Properties

M.Wt 507.6825
Formula C27H41NO6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (1S,3S,7S,10R,11S,12S,16R)-

References

1. Narvi E, et al. Br J Cancer. 2013 Jan 15;108(1):82-90.

2. Ruschel J, et al. Science. 2015 Apr 17;348(6232):347-52.

3. O'Reilly T, et al. Cancer Chemother Pharmacol. 2008 Nov;62(6):1045-54.

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