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Chemical Structure : Lexibulin dihydrochloride
CAS No.: 917111-49-0
Catalog No.: PC-42620Not For Human Use, Lab Use Only.
An orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $136 | In stock | |
| 50 mg | $488 | In stock | |
| 250 mg | Get quote |
Bulk size, bulk discount!
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An orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo; inhibits a broad selection of cancer cell lines with IC50 of <100 nM; blocks the cell cycle at the G2-M boundary and increases phosphorylated Bcl-2, expression of cyclin B1; orally bioavailable, and efficacious in a range of in vivo cancer models.
Blood Cancer
Phase 2 Discontinued
| M.Wt | 507.4559 | |
| Formula | C24H32Cl2N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Urea, N-ethyl-N'-[2-methoxy-4-[5-methyl-4-[[(1S)-1-(3-pyridinyl)butyl]amino]-2-pyrimidinyl]phenyl]-, hydrochloride (1:2) |
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1. Burns CJ, et al. Mol Cancer Ther. 2009 Nov;8(11):3036-45.
2. Burns CJ, et al. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4639-42.
3. Burns CJ, et al. J Pharmacol Exp Ther. 2011 Dec;339(3):799-806.
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