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Fosbretabulin disodium

Chemical Structure : Fosbretabulin disodium

CAS No.: 168555-66-6

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Fosbretabulin disodium (CA4DP, CA4P, Combretastatin A-4 phosphate)

Catalog No.: PC-45268Not For Human Use, Lab Use Only.

Fosbretabulin disodium (CA4DP, Combretastatin A-4) is a derivative of combretastatin that acts as a microtubule destabilising agent, damages the vasculature (blood vessels) of cancer tumours causing central necrosis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Fosbretabulin disodium (CA4DP, Combretastatin A-4) is a derivative of combretastatin that acts as a microtubule destabilising agent, damages the vasculature (blood vessels) of cancer tumours causing central necrosis.

Physicochemical Properties

M.Wt 440.292
Formula C18H19Na2O8P
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

H2O: 4.4 mg/mL (Need ultrasonic and warming); DMSO: < 0.044 mg/mL
Chemical Name/SMILES

Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, 1-(dihydrogen phosphate), sodium salt (1:2)

References

1. Shen CH, et, al. Br J Pharmacol. 2010 Aug;160(8):2008-27.

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