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Ombrabulin

Chemical Structure : Ombrabulin

CAS No.: 181816-48-8

Ombrabulin (AVE8062, AVE 8062A, AC7700, RPR258063)

Catalog No.: PC-70178Not For Human Use, Lab Use Only.

Ombrabulin (AVE8062) is a combretastatin A-4 derivative and tubulin polymerization inhibitor that strongly stanches tumour blood flows and inhibits growth of tumours developing in various tissues and organ..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ombrabulin (AVE8062) is a combretastatin A-4 derivative and tubulin polymerization inhibitor that strongly stanches tumour blood flows and inhibits growth of tumours developing in various tissues and organ.
Ombrabulin is a vascular-disrupting agent under clinical investigation combined with cisplatin/docetaxel or carboplatin/paclitaxel in patients with advanced solid tumors.

Physicochemical Properties

M.Wt 402.45
Formula C21H26N2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S)-2-Amino-3-hydroxy-N-[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]propanamide

References

1. Kim TJ, et al. Cancer Res. 2007 Oct 1;67(19):9337-45.

2. Hori K, et al. Cancer Sci. 2008 Jul;99(7):1485-91.

3. Hori K, et al. Br J Cancer. 2002 May 20;86(10):1604-14.

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