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STK899704

Chemical Structure : STK899704

CAS No.: 1578247-29-6

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STK899704 (STK-899704)

Catalog No.: PC-60252Not For Human Use, Lab Use Only.

STK899704 is a novel tubulin inhibitor that inhibits the proliferation of cancer cell lines with IC50 of 0.2-1.0 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    STK899704 is a novel tubulin inhibitor that inhibits the proliferation of cancer cell lines with IC50 of 0.2-1.0 uM.
    STK899704 suppresses the growth of HeLa cells with IC50 of 350 nM, prevents the polymerization of purified tubulin in vitro.
    STK899704 also depolymerizes microtubule in cultured cells leading to mitotic arrest, associated with increased Cdc25C phosphorylation and the accumulation of both cyclin B1 and Plk1 and apoptosis.
    STK899704 shows anticancer activity in vivo.

    Physicochemical Properties

    M.Wt 453.498
    Formula C27H23N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Ethyl (E)-2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate

    References

    1. Sakchaisri K, et al. PLoS One. 2017 Mar 15;12(3):e0173311.

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