R-huezole

Chemical Structure : R-huezole

Catalog No.: PC-47072Not For Human Use, Lab Use Only.

R-huezole is a phase-separating small molecule that forms liquid droplets to selectively sequester tubulin, enters cultured human cells and prevents cell mitosis by forming tubulin-concentrating condensates in cells.

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Biological Activity

R-huezole is a phase-separating small molecule that forms liquid droplets to selectively sequester tubulin, enters cultured human cells and prevents cell mitosis by forming tubulin-concentrating condensates in cells.

Physicochemical Properties

M.Wt	641.798
Formula	C34H42F3N5O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-((5-benzyl-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-cyclopentylpropanoyl)-3-methylpiperazin-1-yl)pentan-1-one

References

1. Genyir Ado, et al. Chem Sci. 2022 Apr 20;13(19):5760-5766.

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R-huezole

Biological Activity

Physicochemical Properties

References

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