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Chemical Structure : Plinabulin
CAS No.: 714272-27-2
Catalog No.: PC-21390Not For Human Use, Lab Use Only.
Plinabulin (NPI-2358) is a small molecule vascular disrupting agent against tubulin-depolymerizing, shows IC50 of 9.8 nM against HT-29 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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Plinabulin (NPI-2358) is a small molecule vascular disrupting agent against tubulin-depolymerizing, shows IC50 of 9.8 nM against HT-29 cells.
Plinabulin (NPI-2358) exhibits potent interruption of tumor blood flow because of the disruption of tumor vascular endothelial cells, resulting in tumor necrosis.
Plinabulin (NPI-2358) elicits tumor vascular endothelial architectural destabilization leading to selective collapse of established tumor vasculature.
Plinabulin (NPI-2358) also induces apoptotic cell death in MM cell lines and tumor cells from patients with MM, associated with mitotic growth arrest.
Plinabulin (NPI-2358) triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cells.
| M.Wt | 336.39 | |
| Formula | C19H20N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-3-((Z)-benzylidene)-6-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione |
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1. Yamazaki Y, et al. J Med Chem. 2012 Feb 9;55(3):1056-71.
2. Singh AV, et al. Blood. 2011 May 26;117(21):5692-700.
3. Nicholson B, et al. Anticancer Drugs. 2006 Jan;17(1):25-31.
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