Plinabulin (NPI-2358) is a small molecule vascular disrupting agent against tubulin-depolymerizing, shows IC50 of 9.8 nM against HT-29 cells. Plinabulin (NPI-2358) exhibits potent interruption of tumor blood flow because of the disruption of tumor vascular endothelial cells, resulting in tumor necrosis. Plinabulin (NPI-2358) elicits tumor vascular endothelial architectural destabilization leading to selective collapse of established tumor vasculature. Plinabulin (NPI-2358) also induces apoptotic cell death in MM cell lines and tumor cells from patients with MM, associated with mitotic growth arrest. Plinabulin (NPI-2358) triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cells.
