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Chemical Structure : MI-181
Catalog No.: PC-22895Not For Human Use, Lab Use Only.
MI-181 (Mitotic inhibitor-181) is a potent M-phase inhibitor with mitotic arrest IC50 of 23 nM and cell death IC50 of 17 nM, inhibits tubulin polymerization and modulates cilia length and biogenesis.
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MI-181 (Mitotic inhibitor-181) is a potent M-phase inhibitor with mitotic arrest IC50 of 23 nM and cell death IC50 of 17 nM, inhibits tubulin polymerization and modulates cilia length and biogenesis.
MI-181 is a potent cell cycle-specific inhibitor, which arrested cells in mitosis, activated the SAC, and induced an apoptotic cell death with faster kinetics than taxol.
MI-181 is active in a broad array of cancers, especially melanomas (BRAFV600E melanomas, IC50=18-90 nM).
MI-181 is effective at rescuing cilia length and ciliation defects in cells that had been treated with the intraflagellar transport inhibitor Ciliobrevin D or the O-GlcNAc transferase inhibitor OSMI-1.
MI-181 induces an increase in cilia length and restores ciliation in cells with compromised shortened cilia at low nanomolar concentrations.
MI-181 restores ciliation and cilia length in cells with a compromised IFT system.
| M.Wt | 266.36 | |
| Formula | C16H14N2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Senese S, et al. Cell Death Dis. 2014 Oct 16;5(10):e1462.
2. Gholkar AA, et al. ACS Chem Biol. 2024 Aug 6. doi: 10.1021/acschembio.4c00186.
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