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CH-2-77 analogue 60c

Chemical Structure : CH-2-77 analogue 60c

CAS No.: 2757188-21-7

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CH-2-77 analogue 60c

Catalog No.: PC-38804Not For Human Use, Lab Use Only.

CH-2-77 analogue 60c is a potent colchicine-binding site tubulin inhibitor, inhibits tubulin polymerization and is effective against P-glycoprotein-mediated multiple drug resistance and taxol resistance.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CH-2-77 analogue 60c is a potent colchicine-binding site tubulin inhibitor, inhibits tubulin polymerization and is effective against P-glycoprotein-mediated multiple drug resistance and taxol resistance.
    CH-2-77 analogue 60c exhibited a strong inhibitory effect on tumor growth and metastasis in a taxol-resistant A375/TxR xenograft model without obvious toxicity.

    Physicochemical Properties

    M.Wt 397.402
    Formula C22H20FNO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3-fluoro-6-(3-hydroxy-4-methylphenyl)pyridin-2-yl)(3,4,5-trimethoxyphenyl)methanone

    References

    1. Hao Chen, et al. J Med Chem. 2021 Aug 26;64(16):12049-12074.

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