Chemical Structure : EAPB02303
CAS No.:
1958290-51-1
EAPB02303
(EAPB 02303)
Catalog No.: PC-20673Not For Human Use, Lab Use Only.
EAPB02303 (EAPB 02303) is a novel microtubule-disrupting agent with in-vivo activity in PDAC and in-vitro synergy with Paclitaxel, inhibits A375 melanoma cell line with IC50 of 3 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
EAPB02303 (EAPB 02303) is a novel microtubule-disrupting agent with in-vivo activity in PDAC and in-vitro synergy with Paclitaxel, inhibits A375 melanoma cell line with IC50 of 3 nM.
EAPB02303 does not inhibit tubulin polymerization.
EAPB02303 exerts activity at low nanomolar concentrations in-vitro in PDAC cell lines and 3D models, and is able to reduce tumor growth in our xenografts in-vivo mouse models.
EAPB02303 is a potent synergy with Paclitaxel at lower concentrations of both compounds.
EAPB02303 induces mitosis arrest and impairment of spindle assembly.
EAPB02303 treatment reduced tumor size and weight of the A375 human melanoma xenografts in a dose-dependent manner, correlated with a low mitotic index but not with necrosis.
Physicochemical Properties
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M.Wt
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306.33
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Formula
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C17H14N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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OC1=CC=C(C2=CN=C3N2C4=C(C=CC=C4)N=C3NC)C=C1O
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References
1. Patinote C, et al. Eur J Med Chem. 2021 Feb 15;212:113031.
2. Deleuze-Masqeufa C. et al. WO 2009 043934A1.
3. Kevin Bigot, et al. Cancer Res (2023) 83 (7_Supplement): 5729.
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