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Chemical Structure : CH-3-8
Catalog No.: PC-49013Not For Human Use, Lab Use Only.
CH-3-8 is a novel microtubule polymerization inhibitor with little susceptible to transporter-mediated chemoresistance, binds to the colchicine-binding site in tubulin protein, disrupts microtubule dynamics at the nanomolar concentration in MIA PaCa-2 and PANC-1 pancreatic cancer cell lines.
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CH-3-8 is a novel microtubule polymerization inhibitor with little susceptible to transporter-mediated chemoresistance, binds to the colchicine-binding site in tubulin protein, disrupts microtubule dynamics at the nanomolar concentration in MIA PaCa-2 and PANC-1 pancreatic cancer cell lines.
CH-3-8 significantly inhibited the proliferation of these cells, induced G2/M cell cycle arrest, and led to apoptosis.
Systemic administration of CH-3-8 at the dose of 20 mg/kg into orthotopic pancreatic tumor-bearing NSG mice every alternate day resulted in significant tumor regression, without significant toxicity.
| M.Wt | 395.411 | |
| Formula | C22H21NO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rajan Sharma Bhattarai, et al. J Control Release. 2021 Jan 10;329:585-597.
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