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ABP1

Chemical Structure : ABP1

CAS No.: 1482293-92-4

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ABP1 (ABP 1)

Catalog No.: PC-60351Not For Human Use, Lab Use Only.

ABP1 is a nonselective inhibitor of UBL protein-activating E1 enzymes that forms covalent adducts with UBL proteins SUMO1, ubiquitin, Nedd8, ISG15, and GABARAP in the presence of ATP and E1 enzymes in vitro.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ABP1 is a nonselective inhibitor of UBL protein-activating E1 enzymes that forms covalent adducts with UBL proteins SUMO1, ubiquitin, Nedd8, ISG15, and GABARAP in the presence of ATP and E1 enzymes in vitro.
    ABP1 covalently labels not only for canonical E1s (UBE1, SAE1/SAE2, NAE1/UBA3, UBE1L, and UBA6) but also for noncanonical E1s (UBA5 and ATG7).

    Physicochemical Properties

    M.Wt 384.367
    Formula C13H16N6O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(prop-2-yn-1-ylamino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl sulfamate

    References

    1. An H, et al. J Am Chem Soc. 2013 Nov 13;135(45):16948-62.

    2. An H, et al. Chem Sci. 2015 Sep 1;6(9):5235-5245.

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