| Cat. No. |
Product Name |
Information |
| PC-61296 |
OSU-2S
PKCδ activator
|
OSU-2S is a non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency with IC50 of 2.4, 2.4, and 3.5 uM in Huh7, Hep3B, and PLC5 cells, respectively. |
| PC-70263 |
Calphostin C
PKC inhibitor
|
Calphostin C (UCN 1028C, PKF115-584) is a potent, selective and photo-dependent inhibitor of PKC with IC50 of 50 nM. |
| PC-60994 |
AS2521780
PKCθ inhibitor
|
AS2521780 is a potent, selective, orally bioavailable PKCθ inhibitor that inhibits combinant human PKCθ enzyme with IC50 of 0.48 nM, >30-fold higher than other PKC isoforms. |
| PC-60684 |
Go 6976
PKC inhibitor
|
Go 6976 is a potent, selective protein kinase C (PKC) inhibitor that selectively inhibits PKCα and PKCβ1 with IC50 of 2.3 and 6.2 nM, respectively. |
| PC-60366 |
PKC-IN-6c
PKC inhibitor
|
PKC inhibitor 6c (PKC-IN-6c) is a potent, brain permeant PKC inhibitor with IC50 of 80 nM, without detectable binding to the estrogen receptor (Ki>10 uM). |
| PC-42543 |
Sotrastaurin
PKC inhibitor
|
Sotrastaurin (AEB071) is a potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes. |
| PC-42441 |
Ruboxistaurin hydrochloride
PKCβ inhibitor
|
Ruboxistaurin hydrochloride (LY333531) is a potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively. |
| PC-42542 |
Enzastaurin
PKCβ inhibitor
|
Enzastaurin (LY317615) is a potent, selective, ATP-competitive PKCβ inhibitor with IC50 of 6 nM. |
| PC-42473 |
PKC412
PKC inhibitor
|
Midostaurin (CGP-41231, PKC-412) is a potent, selective PKC inhibitor with IC50 of 50 nM. |
| PC-45546 |
Phorbol 12-myristate 13-acetate
PKC activator
|
Phorbol 12-myristate 13-acetate (PMA) is a PKC activator, including group A (α, βI, βII, γ) and group B (δ, ε, η, θ) isoforms. |
| PC-23471 |
Staurosporine
PKC inhibitor, Apoptosis inducer
|
Staurosporine (STS) is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. |
| PC-23429 |
Ruboxistaurin
PKCβ inhibitor
|
Ruboxistaurin (LY333531) is a potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively. |
