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Chemical Structure : Enzastaurin
CAS No.: 170364-57-5
Catalog No.: PC-42542Not For Human Use, Lab Use Only.
Enzastaurin (LY317615) is a potent, selective, ATP-competitive PKCβ inhibitor with IC50 of 6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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Enzastaurin (LY317615) is a potent, selective, ATP-competitive PKCβ inhibitor with IC50 of 6 nM.
Enzastaurin (LY317615) weakly inhibits PKCα, PKCγ, and PKCε with IC50 of 39, 83, and 110 nM, respectively.
Enzastaurin (LY317615) induces apoptosis and suppresses the proliferation of tumor cells, suppresses the phosphorylation of GSK3β Ser9, ribosomal protein S6(S240/244) and AKT(Thr308).
Enzastaurin (LY317615) suppresses tumor growth through multiple mechanism in vivo; orally active.
| M.Wt | 515.605 | |
| Formula | C32H29N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Pyrrole-2,5-dione, 3-(1-methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]- |
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1. Graff JR, et al. Cancer Res. 2005 Aug 15;65(16):7462-9.
2. Faul MM, et al. Bioorg Med Chem Lett. 2003 Jun 2;13(11):1857-9.
3. Querfeld C, et al. J Invest Dermatol. 2006 Jul;126(7):1641-7.
4. Rizvi MA, et al. Mol Cancer Ther. 2006 Jul;5(7):1783-9.
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