| Cat. No. |
Product Name |
Information |
| PC-27816 |
PKN2-IN-1
PKN2 inhibitor
|
PKN2-IN-1 (Compound 8) is a potent, selective and cell penetrant inhibitor of Protein Kinase N2 (PKN2, PRK2) with Ki/IC50 of 8/16 nM, shows 14-fold selectivity over PKN1. |
| PC-27614 |
Ingenol Mebutate
PKC activator
|
Ingenol Mebutate (PEP005, Ingenol 3-angelate) is a selective small-molecule activator of protein kinase C (PKC) with Ki of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively. |
| PC-27349 |
HA-100
PKC/PKA inhibitor
|
HA-100 is a potent Ca2+-dependent protein kinases inhibitor with IC50 of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLCK. |
| PC-24787 |
Acteoside
PKC inhibitor
|
Acteoside (Verbascoside) is a small molecule ATP-competitive inhibitor of protein kinase C (PKC) with IC50 of 25 uM, shows antitumor, anti-inflammatory and antineuropathic pain activity. |
| PC-24452 |
CP612
PKCε inhibitor
|
CP612 (CIDD-0150612) is a potent, specific inhibitor of protein kinase C epsilon (PKC epsilon, PKCε) with IC50 of 1.1 nM, 40-fold more selective against PKCε over ROCK1. |
| PC-23919 |
PKC agonist C-233
PKC-ε agonist
|
PKC agonist C-233 is a selective PKC-ε agonist with EC50 of 240 nM, has 196-fold selectivity over PKC-δ and 5-6 fold over PKC-η and PKC-θ. |
| PC-23426 |
GF109203X
PKC inhibitor
|
GF109203X (Bisindolylmaleimide I) is a potent, cell-permeable and reversible PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ respectively. |
| PC-22772 |
PS428
PRK2 inhibitor
|
PS428 is a small molecule, allosteric inhibitor of protein kinase C-related kinase 2 (PKN2/PRK2), binds to the PIF-pocket of PRK2 and allosterically inhibits activated PRK2. |
| PC-21981 |
CIDD-0072424
PKC epsilon inhibitor
|
CIDD-0072424 is a potent, selective inhibitor of protein kinase C epsilon (PKCε, PKC epsilon) with IC50 of 54 nM, high selectivity over other PKC isoforms. |
| PC-20701 |
CRT0066854
aPKC inhibitor
|
CRT0066854 is a potent and selective chemical inhibitor of atypical PKC (protein kinase C) isoforms PKCζ and PKCι with IC50 of 639 nM and 132 nM, respectively. |
| PC-38836 |
Z640
aPKC agonist
|
Z640 is a novel non-selective atypical PKC (aPKC) agonist, increases PKCζ and PKCι kinase activity with EC50 of 1.09 and 3.47 µM in vitro kinase activity assays, respectively. |
| PC-38356 |
Darovasertib
PKC inhibitor
|
Darovasertib (NVP-LXS196, LXS 196, IDE196) is a potent, selectve, oral pan- protein kinase C (PKC) inhibitor with IC50 of 3 nM and 0.6 nM for PKCα and PKCθ, respectively. |
