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Chemical Structure : GF109203X
CAS No.: 133052-90-1
Catalog No.: PC-23426Not For Human Use, Lab Use Only.
GF109203X (Bisindolylmaleimide I) is a potent, cell-permeable and reversible PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $68 | In stock | |
| 10 mg | $108 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GF109203X (Bisindolylmaleimide I, GF 109203X) is a potent, cell-permeable and reversible PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ respectively.
GF109203X abrogates anti-CD3 antibody-induced upregulation of CD4+ T cell adhesion to B cells.
GF 109203X efficiently prevented PKC-mediated phosphorylations of an Mr = 47,000 protein in platelets and of an Mr = 80,000 protein in Swiss 3T3 cells.
GF 109203X inhibited collagen- and alpha-thrombin-induced platelet aggregation as well as collagen-triggered ATP secretion.
| M.Wt | 412.49 | |
| Formula | C25H24N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(1-(3-(Dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
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1. Hauss P, et al. Cell Immunol. 1993 Sep;150(2):439-46.
2. Toullec D, et al. J Biol Chem. 1991 Aug 25;266(24):15771-81.
3. Faucher C, et al. J Biol Chem. 1993 Jul 15;268(20):15168-73.
4. Paya CV, et al. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7826-30.
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