Catalog No.: PC-23426Not For Human Use, Lab Use Only.
GF109203X (Bisindolylmaleimide I) is a potent, cell-permeable and reversible PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ respectively.
GF109203X (Bisindolylmaleimide I, GF 109203X) is a potent, cell-permeable and reversible PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ respectively. GF109203X abrogates anti-CD3 antibody-induced upregulation of CD4+ T cell adhesion to B cells. GF 109203X efficiently prevented PKC-mediated phosphorylations of an Mr = 47,000 protein in platelets and of an Mr = 80,000 protein in Swiss 3T3 cells. GF 109203X inhibited collagen- and alpha-thrombin-induced platelet aggregation as well as collagen-triggered ATP secretion.
