| Cat. No. |
Product Name |
Information |
| PC-63488 |
PKCiota-IN-51
PKC-iota inhibitor
|
PKCiota-IN-51 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.7 nM, >15-fold selectivity over PKC-α and PKC-β. |
| PC-63224 |
PKCα/β inhibitor Cmpd 1
PKCα/β inhibitor
|
PKCα/β inhibitor Cmpd 1 is a potent and selective inhibitor of Protein Kinase C (PKC) family members PKCα and PKCβ with IC50 of 2 nM and 11 nM, respectively. |
| PC-42969 |
Indolactam V
PKC activator
|
Indolactam V ((-)-Indolactam V) is an indole alkaloid tumor promoter that activates protein kinase C (PKC), binds to PKC regulatory domains of mouse skin PKCη and rat brain PKCγ with Ki values of 3.4 nM and 1 uM, respectively. |
| PC-42863 |
Chelerythrine chloride
PKC inhibitor
|
Chelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK, also inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 uM and displaces Bax from Bcl-XL. |
| PC-62814 |
PKC-IN-7
PKCα/β inhibitor
|
PKC-IN-7 is a potent, selective, reversible, ATP-competitive PKCα/β inhibitor with IC50 of 4.7/3.3 nM. |
| PC-62549 |
p32 inhibitor M36
p32 inhibitor
|
p32 inhibitor M36 is a novel small molecule inhibitor of p32 mitochondrial protein, binds directly to p32 and inhibits p32 association with LyP-1. |
| PC-62477 |
UCN-01
PKC inhibitor
|
UCN-01 (7-Hydroxystaurosporine, NSC 638850) is a synthetic derivative of staurosporine that has antiproliferative activity against several in vitro and in vivo cancer models. |
| PC-62415 |
PS432
PKC inhibitor
|
PS432 is an allosteric inhibitor of PKCι and PKCζ with IC50 of 16.9 and 18.5 uM, respectively. |
| PC-62375 |
BJE6-106
PKCδ inhibitor
|
BJE6-106 (B106) is a potent, selective PKCδ inhibitor with IC50 of 50 nM, displays excellent selectivity over classical PKC isozymes (a 1,000-fold PKCδ selectivity over PKCα). |
| PC-62078 |
LY379196
PKCβ inhibitor
|
LY379196 is a highly specific PKCβ inhibitor with IC50 of 30-50 nM for PKCβI and PKCβII, displays >10-fold selectivity of PKCα, δ, η, and γ (>600 nM). |
| PC-62077 |
CGP-53353
PKCβII inhibitor
|
CGP-53353 (DAPH-7) is a selective inhibitor of PKCβII with IC50 of 0.41 uM, shows weak activity on PKCβI with IC50 of 3.8 uM. |
| PC-61793 |
Rottlerin
PKCδ inhibitor
|
Rottlerin (Mallotoxin, NSC 94525) is a polyphenol natural product, cell-permeable and reversible PKC inhibitor that exhibits greater selectivity for PKCδ (IC50=3-6 uM) and PKCθ, with significantly reduced potency (IC50=30-42 uM) for PKCα, PKCβ, and PKCγ. |
