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PKCiota-IN-51

Chemical Structure : PKCiota-IN-51

CAS No.: 2230052-97-6

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PKCiota-IN-51 (PKC-ι inhibitor 51)

Catalog No.: PC-63488Not For Human Use, Lab Use Only.

PKCiota-IN-51 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.7 nM, >15-fold selectivity over PKC-α and PKC-β.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PKC-ι inhibitor 51 (PKCiota-IN-51) is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.7 nM, >15-fold selectivity over PKC-α and PKC-β.
    PKC-ι inhibitor 51 inhibits PKC-ι on the phosphorylation of substrate ECT2 in HCCLM3 cells with IC50 of 3.3 uM.

    Physicochemical Properties

    M.Wt 427.483
    Formula C25H22FN5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-(5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl)-3-(fluoromethyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

    References

    1. Kwiatkowski J, et al. J Med Chem. 2018 May 4. doi: 10.1021/acs.jmedchem.8b00060.

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