Chemical Structure : ICA-1
CAS No.:
742038-81-9
ICA-1
(PKC-iota inhibitor)
Catalog No.: PC-35336Not For Human Use, Lab Use Only.
ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member.
ICA-1 potently inhibits the phosphorylation of Cdk7 by PKC-ι, inhibits PKC-ι/Cdk7/cdk2 cell signaling pathway and exhibits antiproliferative effects in neuroblastoma cells, also induces apoptosis.
ICA-1 significantly reduces migration and melanoma cell invasion, downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis.
Physicochemical Properties
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M.Wt
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336.241
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Formula
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C10H17N4O7P
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-Amino-1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-1H-imidazole-4-carboxamide
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References
1. Pillai P, et al. Int J Biochem Cell Biol. 2011 May;43(5):784-94.
2. McCray AN, et al. Neurochem Res. 2014 Sep;39(9):1691-701.
3. Ratnayake WS, et al. Cell Adh Migr. 2018 May 21:1-17.
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