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Chemical Structure : Indolactam V
CAS No.: 90365-57-4
Catalog No.: PC-42969Not For Human Use, Lab Use Only.
Indolactam V ((-)-Indolactam V) is an indole alkaloid tumor promoter that activates protein kinase C (PKC), binds to PKC regulatory domains of mouse skin PKCη and rat brain PKCγ with Ki values of 3.4 nM and 1 uM, respectively.
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Indolactam V ((-)-Indolactam V) is an indole alkaloid tumor promoter that activates protein kinase C (PKC), binds to PKC regulatory domains of mouse skin PKCη and rat brain PKCγ with Ki values of 3.4 nM and 1 uM, respectively; induces differentiation of human embryonic stem cells into pancreatic progenitors through activation of PKC signaling.
| M.Wt | 301.3834 | |
| Formula | C17H23N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3H-Pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S,5S)- |
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1. Masuda A, et al. Biosci Biotechnol Biochem. 2002 Jul;66(7):1615-7.
2. Heikkilä J, et al. Biochem Biophys Res Commun. 1989 Aug 15;162(3):1207-13.
3. Chen S, et al. Nat Chem Biol. 2009 Apr;5(4):258-65.
4. Kazanietz MG, et al. Mol Pharmacol. 1993 Aug;44(2):298-307.
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