Indolactam V |CAS:90365-57-4 Probechem Biochemicals

Chemical Structure : Indolactam V

CAS No.: 90365-57-4

Indolactam V ((-)-Indolactam V)

Catalog No.: PC-42969Not For Human Use, Lab Use Only.

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Biological Activity

Indolactam V ((-)-Indolactam V) is an indole alkaloid tumor promoter that activates protein kinase C (PKC), binds to PKC regulatory domains of mouse skin PKCη and rat brain PKCγ with Ki values of 3.4 nM and 1 uM, respectively; induces differentiation of human embryonic stem cells into pancreatic progenitors through activation of PKC signaling.

Physicochemical Properties

M.Wt	301.3834
Formula	C17H23N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3H-Pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S,5S)-

References

1. Masuda A, et al. Biosci Biotechnol Biochem. 2002 Jul;66(7):1615-7.

2. Heikkilä J, et al. Biochem Biophys Res Commun. 1989 Aug 15;162(3):1207-13.

3. Chen S, et al. Nat Chem Biol. 2009 Apr;5(4):258-65.

4. Kazanietz MG, et al. Mol Pharmacol. 1993 Aug;44(2):298-307.

Indolactam V ((-)-Indolactam V)

Biological Activity

Physicochemical Properties

References

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