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Chemical Structure : UCN-01
Catalog No.: PC-62477Not For Human Use, Lab Use Only.
UCN-01 (7-Hydroxystaurosporine.
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UCN-01 (7-Hydroxystaurosporine;NSC 638850) is a synthetic derivative of staurosporine that has antiproliferative activity against several in vitro and in vivo cancer models; inhibits a variety of kinases, including Akt, PKC (IC50=30 nM), PDK1 (IC50=6 nM), CDKs (IC50=300-600 nM for Cdk1 and Cdk2); arrests tumor cells in the G1/S phase of the cell cycle and prevents nucleotide excision repair by Chk1 (IC50=7 nM); induces apoptosis.
| M.Wt | 482.5 | |
| Formula | C28H26N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kawabe T. Mol Cancer Ther. 2004 Apr;3(4):513-9.
2. Peifer C, et al. ChemMedChem. 2008 Dec;3(12):1810-38.
3. Facchinetti MM, et al. Cancer Res. 2004 May 15;64(10):3629-37.
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