UCN-01 |CAS:112953-11-4 Probechem Biochemicals

Chemical Structure : UCN-01

UCN-01 (7-Hydroxystaurosporine, NSC 638850)

Catalog No.: PC-62477Not For Human Use, Lab Use Only.

UCN-01 (7-Hydroxystaurosporine, NSC 638850) is a synthetic derivative of staurosporine that has antiproliferative activity against several in vitro and in vivo cancer models.

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Biological Activity

UCN-01 (7-Hydroxystaurosporine, NSC 638850) is a synthetic derivative of staurosporine that has antiproliferative activity against several in vitro and in vivo cancer models.
UCN-01 inhibits a variety of kinases, including Akt, PKC (IC50=30 nM), PDK1 (IC50=6 nM), CDKs (IC50=300-600 nM for Cdk1 and Cdk2).
UCN-01 arrests tumor cells in the G1/S phase of the cell cycle and prevents nucleotide excision repair by Chk1 (IC50=7 nM).
UCN-01 induces apoptosis.

Physicochemical Properties

M.Wt	482.5
Formula	C28H26N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

References

1. Kawabe T. Mol Cancer Ther. 2004 Apr;3(4):513-9.

2. Peifer C, et al. ChemMedChem. 2008 Dec;3(12):1810-38.

3. Facchinetti MM, et al. Cancer Res. 2004 May 15;64(10):3629-37.

UCN-01 (7-Hydroxystaurosporine, NSC 638850)

Biological Activity

Physicochemical Properties

References

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