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PS428

Chemical Structure : PS428

CAS No.:

PS428 (PS-428)

Catalog No.: PC-22772Not For Human Use, Lab Use Only.

PS428 is a small molecule, allosteric inhibitor of protein kinase C-related kinase 2 (PKN2/PRK2), binds to the PIF-pocket of PRK2 and allosterically inhibits activated PRK2.

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    Biological Activity

    PS428 is a small molecule, allosteric inhibitor of protein kinase C-related kinase 2 (PKN2/PRK2), binds to the PIF-pocket of PRK2 and allosterically inhibits activated PRK2.

    Physicochemical Properties

    M.Wt 505.50
    Formula C25H19N3O7S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    ethyl 4-hydroxy-1-(6-methylbenzo[d]thiazol-2-yl)-2-(5-(3-nitrophenyl)furan-2-yl)-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate

    References

    1. Gross LZF, et al. J Biol Chem. 2024 Jul 11:107550.

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