PS428 | PRK2 inhibitor | Probechem Biochemicals

Chemical Structure : PS428

PS428 (PS-428)

Catalog No.: PC-22772Not For Human Use, Lab Use Only.

PS428 is a small molecule, allosteric inhibitor of protein kinase C-related kinase 2 (PKN2/PRK2), binds to the PIF-pocket of PRK2 and allosterically inhibits activated PRK2.

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Biological Activity

PS428 is a small molecule, allosteric inhibitor of protein kinase C-related kinase 2 (PKN2/PRK2), binds to the PIF-pocket of PRK2 and allosterically inhibits activated PRK2.

Physicochemical Properties

M.Wt	505.50
Formula	C25H19N3O7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 4-hydroxy-1-(6-methylbenzo[d]thiazol-2-yl)-2-(5-(3-nitrophenyl)furan-2-yl)-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate

References

1. Gross LZF, et al. J Biol Chem. 2024 Jul 11:107550.

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PS428 (PS-428)

Biological Activity

Physicochemical Properties

References

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