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Chemical Structure : Rottlerin
Catalog No.: PC-61793Not For Human Use, Lab Use Only.
Rottlerin (Mallotoxin.
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Rottlerin (Mallotoxin;NSC 94525) is a polyphenol natural product, cell-permeable and reversible PKC inhibitor that exhibits greater selectivity for PKCδ (IC50=3-6 uM) and PKCθ, with significantly reduced potency (IC50=30-42 uM) for PKCα, PKCβ, and PKCγ; also inhibits CaMK III, suppresses eEF-2 phosphorylation with IC50 of 5.3 uM; also remarkably inhibits MACC1 promoter activity and expression, reduces cell motility in CRC cells.
| M.Wt | 516.54 | |
| Formula | C30H28O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Villalba M, et al. J Immunol. 1999 Dec 1;163(11):5813-9.
2. Gschwendt M, et al. FEBS Lett. 1994 Jan 24;338(1):85-8.
3. Juneja M, et al. PLoS Biol. 2017 Jun 1;15(6):e2000784.
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