Catalog No.: PC-61793Not For Human Use, Lab Use Only.
Rottlerin (Mallotoxin, NSC 94525) is a polyphenol natural product, cell-permeable and reversible PKC inhibitor that exhibits greater selectivity for PKCδ (IC50=3-6 uM) and PKCθ, with significantly reduced potency (IC50=30-42 uM) for PKCα, PKCβ, and PKCγ.
Rottlerin (Mallotoxin, NSC 94525) is a polyphenol natural product, cell-permeable and reversible PKC inhibitor that exhibits greater selectivity for PKCδ (IC50=3-6 uM) and PKCθ, with significantly reduced potency (IC50=30-42 uM) for PKCα, PKCβ, and PKCγ.
Rottlerin (Mallotoxin, NSC 94525) also inhibits CaMK III, suppresses eEF-2 phosphorylation with IC50 of 5.3 uM.
Rottlerin (Mallotoxin, NSC 94525) also remarkably inhibits MACC1 promoter activity and expression, reduces cell motility in CRC cells.
