Go 6976 is a potent, selective protein kinase C (PKC) inhibitor that selectively inhibits PKCα and PKCβ1 with IC50 of 2.3 and 6.2 nM, respectively.
Go 6976 shows no effect on the kinase activity of PKCδ, -ε and -ζ (IC50>3 uM).
Go 6976 also inhibits JAK2, FLT3 and mutant FLT3 with significant activity in primary acute myeloid leukaemia cells.
Go 6976 inhibits HIV-1 proviral induction from latent/low-level-producing infectious states, inhibits signalling, survival and proliferation in cells expressing the leukaemia-associated TEL-JAK2 fusion protein and the MPD-associated JAK2 V617F mutant.
