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Chemical Structure : Go 6976
CAS No.: 136194-77-9
Catalog No.: PC-60684Not For Human Use, Lab Use Only.
Go 6976 is a potent, selective protein kinase C (PKC) inhibitor that selectively inhibits PKCα and PKCβ1 with IC50 of 2.3 and 6.2 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $148 | In stock | |
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Go 6976 is a potent, selective protein kinase C (PKC) inhibitor that selectively inhibits PKCα and PKCβ1 with IC50 of 2.3 and 6.2 nM, respectively.
Go 6976 shows no effect on the kinase activity of PKCδ, -ε and -ζ (IC50>3 uM).
Go 6976 also inhibits JAK2, FLT3 and mutant FLT3 with significant activity in primary acute myeloid leukaemia cells.
Go 6976 inhibits HIV-1 proviral induction from latent/low-level-producing infectious states, inhibits signalling, survival and proliferation in cells expressing the leukaemia-associated TEL-JAK2 fusion protein and the MPD-associated JAK2 V617F mutant.
| M.Wt | 378.43 | |
| Formula | C24H18N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile |
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1. Martiny-Baron G, et al. J Biol Chem. 1993 May 5;268(13):9194-7.
2. Qatsha KA, et al. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4674-8.
3. Pätzold S, et al. Antiviral Res. 1993 Dec;22(4):273-83.
4. Grandage VL, et al. Br J Haematol. 2006 Nov;135(3):303-16.
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