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PKC-IN-6c

Chemical Structure : PKC-IN-6c

CAS No.: 2026603-86-9

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PKC-IN-6c (PKC inhibitor 6c)

Catalog No.: PC-60366Not For Human Use, Lab Use Only.

PKC inhibitor 6c (PKC-IN-6c) is a potent, brain permeant PKC inhibitor with IC50 of 80 nM, without detectable binding to the estrogen receptor (Ki>10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PKC inhibitor 6c (PKC-IN-6c) is a potent, brain permeant PKC inhibitor with IC50 of 80 nM, without detectable binding to the estrogen receptor (Ki>10 uM).
    PKC-IN-6c effectively blocks amphetamine-induced locomotor stimulation, more potently inhibits PKC than tamoxifen and reduces amphetamine-stimulated dopamine efflux.

    Physicochemical Properties

    M.Wt 565.762
    Formula C35H43N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3,3-bis(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-2-phenylacrylonitrile

    References

    1. Newman AH, et al. Neuropsychopharmacology. 2017 Jun 8. doi: 10.1038/npp.2017.116.

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