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CGP-53353

Chemical Structure : CGP-53353

CAS No.: 145915-60-2

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CGP-53353 (DAPH-7, CGP53353)

Catalog No.: PC-62077Not For Human Use, Lab Use Only.

CGP-53353 (DAPH-7) is a selective inhibitor of PKCβII with IC50 of 0.41 uM, shows weak activity on PKCβI with IC50 of 3.8 uM.

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5 mg $158 In stock
10 mg $238 In stock
25 mg $398 In stock
50 mg $588 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CGP-53353 (DAPH-7) is a selective inhibitor of PKCβII with IC50 of 0.41 uM, shows weak activity on PKCβI with IC50 of 3.8 uM.
CGP-53353 also inhibits prionogenic Sup35 fibrillization (IC50= 3.4 uM) and inhibits de novo Aβ42 assembly in vitro.

Physicochemical Properties

M.Wt 365.34
Formula C20H13F2N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione

References

1. Kouroedov A, et al. Circulation. 2004 Jul 6;110(1):91-6.

2. Wang H, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7159-64.

3. Chalfant CE, et al. Mol Endocrinol. 1996 Oct;10(10):1273-81.

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