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Chemical Structure : Calphostin C
Catalog No.: PC-70263Not For Human Use, Lab Use Only.
A potent, selective and photo-dependent inhibitor of PKC with IC50 of 50 nM.
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A potent, selective and photo-dependent inhibitor of PKC with IC50 of 50 nM; displays >1,000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase; inhibits cell growth and promotes apoptosis in HeLa S3 and MCF-7 cells with IC50 of 0.23 and 0.18 uM, respectively; also inhibits phospholipase D1 and D2 (IC50=100 nM); also blocks β-catenin/Tcf transcriptional activity.
Solid Tumors
Discontinued
| M.Wt | 790.76 | |
| Formula | C44H38O14 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sukhdeo K, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7516-21.
2. Kobayashi E, et al. J Antibiot (Tokyo). 1989 Oct;42(10):1470-4.
3. Sciorra VA, et al. Biochemistry. 2001 Feb 27;40(8):2640-6.
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