Ruboxistaurin hydrochloride (LY333531) | PKCβ inhibitor

Chemical Structure : Ruboxistaurin hydrochloride

CAS No.: 169939-93-9

Ruboxistaurin hydrochloride (LY333531 hydrochloride, LY-333531 hydrochloride)

Catalog No.: PC-42441Not For Human Use, Lab Use Only.

Ruboxistaurin hydrochloride (LY333531) is a potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively.

Packing	Price	Stock
5 mg	$148	In stock
10 mg	$218	In stock
25 mg	$378	In stock
50 mg	$598	In stock
100 mg		Get quote

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Biological Activity

Ruboxistaurin hydrochloride (LY333531) is a potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively.
Ruboxistaurin hydrochloride (LY333531) displays >60-fold selectivity over PKCα, and other ATP dependent kinases (PKA, Calcium calmodulin, Caesin kinase and Src).
Ruboxistaurin hydrochloride (LY333531) ameliorates the glomerular filtration rate, albumin excretion rate, and retinal circulation in diabetic rats.

Physicochemical Properties

M.Wt	505.0079
Formula	C28H29ClN4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 6.8 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES	9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione, 9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-, monohydrochloride, (9S)- (9CI)

References

1. Jirousek MR, et al. J Med Chem. 1996 Jul 5;39(14):2664-71.

2. Ishii H, et al. Science. 1996 May 3;272(5262):728-31.

Ruboxistaurin hydrochloride (LY333531 hydrochloride, LY-333531 hydrochloride)

Biological Activity

Physicochemical Properties

References

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