Midostaurin (CGP41231, PKC-412) |CAS:120685-11-2 Probechem Biochemicals

Chemical Structure : PKC412

CAS No.: 120685-11-2

PKC412 (CGP-41231;CGP-41251;Midostaurin;PKC-412;CGP41231;CGP41251)

Catalog No.: PC-42473Not For Human Use, Lab Use Only.

Midostaurin (CGP41231, PKC-412) is a potent, selective PKC inhibitor with IC50 of 50 nM, also inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 of 20-500 nM.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$258	In stock
50 mg	$428	In stock
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Biological Activity

Midostaurin (CGP41231, PKC-412) is a potent, selective PKC inhibitor with IC50 of 50 nM, also inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 of 20-500 nM.
Midostaurin (CGP41231, PKC-412) displays a high degree of selectivity over PKA (IC50=2.4 uM), S6 kinase (IC50=5.0 uM) and EGFR (IC50=3.0 uM) compared with Staurosporine.
Midostaurin (CGP41231, PKC-412) inhibits human brain tumors cells (mean IC50=0.4 uM), displays antitumor activity in vivo.

Physicochemical Properties

M.Wt	570.6371
Formula	C35H30N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 21 mg/mL
Chemical Name/SMILES	Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-

References

1. Meyer T, et al. Int J Cancer. 1989 May 15;43(5):851-6.

2. Krause KH, et al. Eur J Pharmacol. 1992 Oct 1;227(2):221-4.

3. Amon U, et al. Pharmacology. 1993 Sep;47(3):200-8.

4. Begemann M, et al. Clin Cancer Res. 1996 Jun;2(6):1017-30.

PKC412 (CGP-41231;CGP-41251;Midostaurin;PKC-412;CGP41231;CGP41251)

Biological Activity

Physicochemical Properties

References

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