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Chemical Structure : PKC412
CAS No.: 120685-11-2
Catalog No.: PC-42473Not For Human Use, Lab Use Only.
Midostaurin (CGP-41231, PKC-412) is a potent, selective PKC inhibitor with IC50 of 50 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $96 | In stock | |
| 10 mg | $152 | In stock | |
| 50 mg | $432 | In stock | |
| 100 mg | Get quote |
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Midostaurin (CGP-41231, PKC-412) is a potent, selective PKC inhibitor with IC50 of 50 nM.
Midostaurin (CGP-41231, PKC-412) displays a high degree of selectivity over PKA (IC50=2.4 uM), S6 kinase (IC50=5.0 uM) and EGFR (IC50=3.0 uM) compared with Staurosporine.
Midostaurin (CGP-41231, PKC-412) inhibits human brain tumors cells (mean IC50=0.4 uM), displays antitumor activity in vivo.
| M.Wt | 570.6371 | |
| Formula | C35H30N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 21 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl- |
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2. Krause KH, et al. Eur J Pharmacol. 1992 Oct 1;227(2):221-4.
3. Amon U, et al. Pharmacology. 1993 Sep;47(3):200-8.
4. Begemann M, et al. Clin Cancer Res. 1996 Jun;2(6):1017-30.
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