Sotrastaurin (AEB071) is a potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes.
Sotrastaurin (AEB071) displays excellent selectivity against a broad panel of kinases (only GSK-3β IC50<1 uM).
Sotrastaurin (AEB071) inhibits early T-cell activation with no general antiproliferative activity, also inhibits β2-integrin-mediated T-cell adhesiveness.
Sotrastaurin (AEB071) prolongs rat heterotopic heart transplant survival in combination with adjunct immunosuppression agents.
