Chemical Structure : OSU-2S
CAS No.:
1351056-65-9
OSU-2S
(OSU 2S)
Catalog No.: PC-61296Not For Human Use, Lab Use Only.
A non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency with IC50 of 2.4, 2.4, and 3.5 uM in Huh7, Hep3B, and PLC5 cells, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
A non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency with IC50 of 2.4, 2.4, and 3.5 uM in Huh7, Hep3B, and PLC5 cells, respectively; exhibited higher in vitro antiproliferative efficacy relative to FTY720 against HCC cells without cytotoxicity in normal hepatocytes, although devoid of S1P1 receptor activity; induces caspase-dependent apoptosis through ROS-dependent PKCδ activation in HCC tumor cells.
Physicochemical Properties
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M.Wt
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335.532
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Formula
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C21H37NO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-2-amino-2-(4-[(6-methylheptyl)-oxy]phenethyl)pentan-1-ol
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References
1. Omar HA, et al. Hepatology. 2011 Jun;53(6):1943-58.
2. Mani R, et al. Leukemia. 2015 Feb;29(2):346-55.
3. Mani R, et al. Exp Hematol. 2015 Sep;43(9):770-4.e2.
4. Omar HA, et al. Front Pharmacol. 2016 Nov 30;7:463. eCollection 2016.
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