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Chemical Structure : OSU-2S
Catalog No.: PC-61296Not For Human Use, Lab Use Only.
A non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency with IC50 of 2.4, 2.4, and 3.5 uM in Huh7, Hep3B, and PLC5 cells, respectively.
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A non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency with IC50 of 2.4, 2.4, and 3.5 uM in Huh7, Hep3B, and PLC5 cells, respectively; exhibited higher in vitro antiproliferative efficacy relative to FTY720 against HCC cells without cytotoxicity in normal hepatocytes, although devoid of S1P1 receptor activity; induces caspase-dependent apoptosis through ROS-dependent PKCδ activation in HCC tumor cells.
| M.Wt | 335.532 | |
| Formula | C21H37NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Omar HA, et al. Hepatology. 2011 Jun;53(6):1943-58.
2. Mani R, et al. Leukemia. 2015 Feb;29(2):346-55.
3. Mani R, et al. Exp Hematol. 2015 Sep;43(9):770-4.e2.
4. Omar HA, et al. Front Pharmacol. 2016 Nov 30;7:463. eCollection 2016.
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