| Cat. No. |
Product Name |
Information |
| PC-49222 |
KPT-276
CRM1 inhibitor
|
KPT-276 (KPT276) is an orally bioavailable selective inhibitor of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of this protein, shows antileukemic activity in vitro and in vivo in acute myeloid leukemia (AML). |
| PC-49221 |
KPT-185
CRM1 inhibitor
|
KPT-185 (KPT185) is a potent, selective inhibitor of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of this protein, shows antileukemic activity in vitro and in vivo in acute myeloid leukemia (AML). |
| PC-49183 |
LFS-829
CRM1 inhibitor
|
LFS-829 (LFS829) is a potent, covalent, small-molecule antagonist of exportin-1 (CRM1) with binding Kd values of 26.95 nM in SPR assays, forms a covalent bond with the sulfur atom of Cys539 126 located in the NES binding cleft of CRM1. |
| PC-35933 |
Verdinexor
CRM1 inhibitor
|
Verdinexor (KPT-335, KPT335) is an orally bioavailable, selective inhibitor of nuclear export (SINE), inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1) and the viability of Jurkat and canine DLBCL cells with IC50 of 8.7 nM and 13.3 nM, respectively. |
| PC-35581 |
Selinexor
CRM1 inhibitor
|
Selinexor (KPT-330, KPT330) is a potent, orally available, selective inhibitor of nuclear export (SINE) targeting CRM1 (XPO1). |
| PC-61270 |
KPT-251
CRM1 inhibitor
|
KPT-251 (KPT251) is a small-molecule, selective inhibitor of nuclear export (CRM1 inhibitor, SINE) that exhibits potent antileukemic activity. |
| PC-70229 |
Leptomycin B
CRM1 inhibitor
|
Leptomycin B (CI 940, Elactocin, Mantuamycin) is a potent and specific nuclear export inhibitor that binds to and inhibits CRM1 (XPO1). |
| PC-42151 |
KPT-8602 Z-isomer
CRM1 inhibitor
|
KPT-8602 Z-isomer is the Z-isomer of Eltanexor (KPT-8602), which is a second-generation SINE with markedly reduced brain penetration compared to selinexor. |
| PC-42150 |
Eltanexor
CRM1 inhibitor
|
Eltanexor (KPT-8602) is a second-generation SINE, orally bioavailable Exportin 1 (XPO1,CRM1) inhibitor with markedly reduced brain penetration compared to selinexor (30-fold less). |
| PC-23730 |
CRM1 inhibitor S109
CRM1 inhibitor
|
CRM1 inhibitor S109 is a specific, reversible inhibitor of CRM1 (exportin 1, XPO1), inhibits cell viability with IC50 of 1.2 uM and 0.97 μM in HCT-15 and HT-29 cells, can induce CRM1 protein degradation. |
| PC-23458 |
CBS9106
CRM1 inhibitor
|
CBS9106 (Felezonexor) is a reversible oral CRM1/exportin1 inhibitor, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a broad spectrum of cancer cells. |
| PC-23457 |
SZJK-0421
CRM1 inhibitor
|
SZJK-0421 is a potent, selective second-generation reversible exportin-1 (CRM1) inhibitor with IC50 of 87.1 nM against MM1S cells. |
