Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SZJK-0421
Catalog No.: PC-23457Not For Human Use, Lab Use Only.
SZJK-0421 is a potent, selective second-generation reversible exportin-1 (CRM1) inhibitor with IC50 of 87.1 nM against MM1S cells.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SZJK-0421 is a potent, selective second-generation reversible exportin-1 (CRM1) inhibitor with IC50 of 87.1 nM against MM1S cells.
SZJK-0421 is more active than KPT-8602 in both hematological tumors Mv-4–11, MOLM-13 and solid tumors HCT-116, BXPC-3, AN3CA.
SZJK-0421 inhibits nuclear export of CRM1. SZJK-0421 effectively inhibited the growth of both hematological and solid tumors, with no significant side effects during administration.
SZJK-0421 covalently bound to CRM1 protein, but the binding was more reversible.
| M.Wt | 458.32 | |
| Formula | C18H12F6N6O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Wang J, et al. Acta Pharm Sin B. 2024 Jul;14(7):3281-3285.
2. Miao H, et al. J Med Chem. 2024 Nov 7. doi: 10.1021/acs.jmedchem.4c02169.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
