Chemical Structure : SZJK-0421
CAS No.:
2664050-18-2
SZJK-0421
(SZJK0421)
Catalog No.: PC-23457Not For Human Use, Lab Use Only.
SZJK-0421 is a potent, selective second-generation reversible exportin-1 (CRM1) inhibitor with IC50 of 87.1 nM against MM1S cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SZJK-0421 is a potent, selective second-generation reversible exportin-1 (CRM1) inhibitor with IC50 of 87.1 nM against MM1S cells.
SZJK-0421 is more active than KPT-8602 in both hematological tumors Mv-4–11, MOLM-13 and solid tumors HCT-116, BXPC-3, AN3CA.
SZJK-0421 inhibits nuclear export of CRM1. SZJK-0421 effectively inhibited the growth of both hematological and solid tumors, with no significant side effects during administration.
SZJK-0421 covalently bound to CRM1 protein, but the binding was more reversible.
Physicochemical Properties
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M.Wt
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458.32
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Formula
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C18H12F6N6O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N-methoxy-2-(pyrimidin-5-yl)acrylamide
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References
1. Wang J, et al. Acta Pharm Sin B. 2024 Jul;14(7):3281-3285.
2. Miao H, et al. J Med Chem. 2024 Nov 7. doi: 10.1021/acs.jmedchem.4c02169.
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