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Chemical Structure : Eltanexor
CAS No.: 1642300-52-4
Catalog No.: PC-42150Not For Human Use, Lab Use Only.
Eltanexor (KPT-8602) is a second-generation SINE, orally bioavailable Exportin 1 (XPO1,CRM1) inhibitor with markedly reduced brain penetration compared to selinexor (30-fold less).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
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Eltanexor (KPT-8602) is a second-generation SINE, orally bioavailable Exportin 1 (XPO1,CRM1) inhibitor with markedly reduced brain penetration compared to selinexor (30-fold less).
Eltanexor (KPT-8602) inhibits viability of human AML cell lines in vitro with IC50 of 20−211 nM, more active than the first-generation XPO1 inhibitor, selinexor.
Eltanexor (KPT-8602) exhibits greater anti-leukemic efficacy against both leukemic blasts and LICs in AML patient-derived xenograft models, with no effect on normal hematopoietic stem and progenitor cell (HSPC) frequency.
| M.Wt | 428.2913 | |
| Formula | C17H10F6N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 4.72 mg/mL |
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| Chemical Name/SMILES |
5-Pyrimidineacetamide, α-[[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]methylene]-, (αE)- |
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1. Etchin J, et al. Leukemia. 2017 Jan;31(1):143-150.
2. Hing ZA, et al. Leukemia. 2016 Dec;30(12):2364-2372.
3. Vercruysse T, et al. Clin Cancer Res. 2017 May 15;23(10):2528-2541.
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