Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Leptomycin B
CAS No.: 87081-35-4
Catalog No.: PC-70229Not For Human Use, Lab Use Only.
Leptomycin B (CI 940, Elactocin, Mantuamycin) is a potent and specific nuclear export inhibitor that binds to and inhibits CRM1 (XPO1).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $158 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Leptomycin B (CI 940, Elactocin, Mantuamycin) is a potent and specific nuclear export inhibitor that binds to and inhibits CRM1 (XPO1).
Leptomycin B blocks the cell cycle and shows potent anti-tumor activity.
Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and inhibits the inactivation of p53.
| M.Wt | 504.74 | |
| Formula | C33H48O6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid |
|
1. Fornerod M, et al. Cell. 1997 Sep 19;90(6):1051-60.
2. Kudo N, et al. Exp Cell Res. 1998 Aug 1;242(2):540-7.
3. Ossareh-Nazari B, et al. Science. 1997 Oct 3;278(5335):141-4.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
