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Chemical Structure : KPT-251
CAS No.: 1388841-50-6
Catalog No.: PC-61270Not For Human Use, Lab Use Only.
KPT-251 (KPT251) is a small-molecule, selective inhibitor of nuclear export (CRM1 inhibitor, SINE) that exhibits potent antileukemic activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 25 mg | $388 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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KPT-251 (KPT251) is a small-molecule, selective inhibitor of nuclear export (CRM1 inhibitor, SINE) that exhibits potent antileukemic activity.
KPT-251 induces apoptosis at nanomolar concentrations in a panel of human AML cell lines with negligible toxicity to normal hematopoietic cells.
| M.Wt | 375.23 | |
| Formula | C14H7F6N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[(1Z)-2-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]ethenyl]-1,3,4-oxadiazole |
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1. Etchin J, et al. Leukemia. 2013 Jan;27(1):66-74.
2. Salas Fragomeni RA, et al. Mol Cancer Ther. 2013 Jul;12(7):1171-9.
3. Cheng Y, et al. Mol Cancer Ther. 2014 Mar;13(3):675-86.
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