Chemical Structure : KPT-251
CAS No.:
1388841-50-6
KPT-251
(KPT 251;KPT251)
Catalog No. : PC-61270Not For Human Use, Lab Use Only.
KPT-251 (KPT251) is a small-molecule, selective inhibitor of nuclear export (CRM1 inhibitor, SINE) that exhibits potent antileukemic activity.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6127001
Biological Activity
KPT-251 (KPT251) is a small-molecule, selective inhibitor of nuclear export (CRM1 inhibitor, SINE) that exhibits potent antileukemic activity.
Physicochemical Properties
M.Wt
375.23
Formula
C14H7F6N5O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-[(1Z)-2-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]ethenyl]-1,3,4-oxadiazole
References
1. Etchin J, et al. Leukemia.
2. Salas Fragomeni RA, et al. Mol Cancer Ther.
3. Cheng Y, et al. Mol Cancer Ther.
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