KPT-8602 Z-isomer | CRM1 inhibitor | Probechem Biochemicals

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Chemical Structure : KPT-8602 Z-isomer

CAS No.: 1642300-78-4

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KPT-8602 Z-isomer (Eltanexor Z-isomer, KPT8602 Z-isomer)

Catalog No.: PC-42151Not For Human Use, Lab Use Only.

KPT-8602 Z-isomer is the Z-isomer of Eltanexor (KPT-8602), which is a second-generation SINE with markedly reduced brain penetration compared to selinexor.

Packing	Price	Stock
5 mg	$238	In stock
10 mg	$368	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KPT-8602 Z-isomer is the Z-isomer of Eltanexor (KPT-8602), which is a second-generation SINE with markedly reduced brain penetration compared to selinexor.

Physicochemical Properties

M.Wt	428.2913
Formula	C17H10F6N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO
Chemical Name/SMILES	5-Pyrimidineacetamide, α-[[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]methylene]-, (αZ)-

References

1. Etchin J, et al. Leukemia. 2017 Jan;31(1):143-150.

2. Hing ZA, et al. Leukemia. 2016 Dec;30(12):2364-2372.

3. Vercruysse T, et al. Clin Cancer Res. 2017 May 15;23(10):2528-2541.

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KPT-8602 Z-isomer (Eltanexor Z-isomer, KPT8602 Z-isomer)

Biological Activity

Physicochemical Properties

References

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