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Chemical Structure : Verdinexor
CAS No.: 1392136-43-4
Catalog No.: PC-35933Not For Human Use, Lab Use Only.
Verdinexor (KPT-335, KPT335) is an orally bioavailable, selective inhibitor of nuclear export (SINE), inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1) and the viability of Jurkat and canine DLBCL cells with IC50 of 8.7 nM and 13.3 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $358 | In stock | |
| 100 mg | $858 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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Verdinexor (KPT-335, KPT335) is an orally bioavailable, selective inhibitor of nuclear export (SINE), inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1) and the viability of Jurkat and canine DLBCL cells with IC50 of 8.7 nM and 13.3 nM, respectively.
KPT-335 induces apoptosis in CLBL1 cells and primary canine DLBCL cells.
KPT-335 reduces influenza a virus replication in vitro and in vivo.
KPT-335 also inhibits XPO1-mediated transport and reduces RSV replication in vitro, shows effectivity against RSV A and B strains and reduces viral replication following prophylactic or therapeutic administration.
| M.Wt | 441.337 | |
| Formula | C19H13F6N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N-(pyridin-2-ylmethyl)acrylamide |
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1. London CA, et al. PLoS One. 2014 Feb 4;9(2):e87585.
2. Perwitasari O, et al. J Virol. 2014 Sep 1;88(17):10228-43.
3. Perwitasari O, et al. PLoS One. 2016 Nov 28;11(11):e0167221.
4. Jorquera PA, et al. J Virol. 2018 Dec 12. pii: JVI.01684-18.
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