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Cat. No. Product Name CAS No. Information
PC-42142

MLi-2

1627091-47-7 MLi2 is a potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76 nM, cellular IC50 of 1.4 nM (dephosphorylation of LRRK2 pSer935 LRRK2).
PC-45425

GNE-7915 tosylate

2070015-00-6 GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM.
PC-45424

GNE-7915

1351761-44-8 A highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM.
PC-72161

G2019S-LRRK2 inhibitor 38

2704564-03-2 G2019S-LRRK2 inhibitor 38 is a potent, selective, brain penetrant G2019S-LRRK2 kinase inhibitor with IC50 of <1 nM, cellular EC50 of 40 nM, >2,000-fold selectivity over WT LRRK2 (cellular EC50>100 uM).
PC-72160

EB-42486

2390475-81-5 EB-42486 (EB42486) is a potent, highly selective G2019S-LRRK2 kinase inhibitor with biochemical IC50 of <0.2 nM.
PC-43416

GSK2578215A

1285515-21-0 GSK2578215A is a highly potent, selective, BBB-permeable LRRK2 inhibitor with IC50 of 10.9 and 9.9 nM for wild-type LRRK2 and the G2019S mutant, respectively.
PC-43053

PF-06447475

1527473-33-1 PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 of 3 and 11nM for WT LRRK2 and G2019S mutant, respectively.

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