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Chemical Structure : CZC-25146
CAS No.: 1191911-26-8
Catalog No.: PC-22263Not For Human Use, Lab Use Only.
CZC-25146 is a potent and selective inhibitor of wild-type LRRK2 and LRRK2 G2019S mutant with IC50 of 4.76 nM and 6.87 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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CZC-25146 is a potent and selective inhibitor of wild-type LRRK2 and LRRK2 G2019S mutant with IC50 of 4.76 nM and 6.87 nM, respectively.
CZC-25146 prevents mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency.
CZC-25146 attenuates G2019S LRRK2-induced human neuronal injury with EC50 of 4 nM, completely blocks G2019S LRRK2 and R1441C-induced toxicity at higher concentrations.
| M.Wt | 488.54 | |
| Formula | C22H25FN6O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-((5-Fluoro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide |
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1. Ramsden N, et al. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.
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