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PF-06447475

Chemical Structure : PF-06447475

CAS No.: 1527473-33-1

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PF-06447475 (PF-475, PF06447475)

Catalog No.: PC-22144Not For Human Use, Lab Use Only.

PF-06447475 is a highly potent, selective and brain penetrant LRRK2 inhibitor with IC50 of 3 nM, also inhibits STE20 kinase family MST1/MST2 with IC50 of 22 nM (MST2).

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10 mg $78 In stock
25 mg $138 In stock
50 mg $228 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-06447475 is a highly potent, selective and brain penetrant LRRK2 inhibitor with IC50 of 3 nM, also inhibits STE20 kinase family MST1/MST2 with IC50 of 22 nM (MST2).

Physicochemical Properties

M.Wt 305.34
Formula C17H15N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-Morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

References

1. Henderson JL, et al. J Med Chem. 2015 Jan 8;58(1):419-32.

2. Daher JP, et al. J Biol Chem. 2015 Aug 7;290(32):19433-44.

3. Mendivil-Perez M, et al. Neurochem Res. 2016 Oct;41(10):2675-2692.

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