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Chemical Structure : PF-06447475
CAS No.: 1527473-33-1
Catalog No.: PC-22144Not For Human Use, Lab Use Only.
PF-06447475 is a highly potent, selective and brain penetrant LRRK2 inhibitor with IC50 of 3 nM, also inhibits STE20 kinase family MST1/MST2 with IC50 of 22 nM (MST2).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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PF-06447475 is a highly potent, selective and brain penetrant LRRK2 inhibitor with IC50 of 3 nM, also inhibits STE20 kinase family MST1/MST2 with IC50 of 22 nM (MST2).
| M.Wt | 305.34 | |
| Formula | C17H15N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(4-Morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile |
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1. Henderson JL, et al. J Med Chem. 2015 Jan 8;58(1):419-32.
2. Daher JP, et al. J Biol Chem. 2015 Aug 7;290(32):19433-44.
3. Mendivil-Perez M, et al. Neurochem Res. 2016 Oct;41(10):2675-2692.
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