| Cat. No. |
Product Name |
Information |
| PC-49302 |
G2019S-LRRK2 inhibitor 22
G2019S-LRRK2 inhibitor
|
G2019S-LRRK2 inhibitor 22 is a novel potent, BBB-penetrant, G2019S-LRRK2 selective kinase inhibitor with IC50 of 4.6 nM, >700-fold selectivity over WT LRRK2. |
| PC-38909 |
DNL201
LRRK2 inhibitor
|
DNL201 (GNE0877) is a first-in-class, CNS-penetrant, selective, ATP-competitive, small-molecule LRRK2 kinase inhibitor with IC50 of 3 nM. |
| PC-43053 |
PF-06447475
LRRK2 inhibitor
|
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 of 3 and 11nM for WT LRRK2 and G2019S mutant, respectively. |
| PC-42142 |
MLi-2
LRRK2 inhibitor
|
MLi2 is a potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76 nM, cellular IC50 of 1.4 nM (dephosphorylation of LRRK2 pSer935 LRRK2). |
| PC-45425 |
GNE-7915 tosylate
|
GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM. |
| PC-45424 |
GNE-7915
LRRK2 inhibitor
|
GNE-7915 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM. |
| PC-22144 |
PF‐06447475
LRRK2
|
PF-06447475 is a highly potent, selective and brain penetrant LRRK2 inhibitor with IC50 of 3 nM, also inhibits STE20 kinase family MST1/MST2 with IC50 of 22 nM (MST2). |
| PC-21889 |
MLi-2
LRRK2 inhibitor
|
MLi-2 is a potent, highly selective, orally available, brain-penetrant inhibitor of LRRK2 with IC50 of 0.76 nM, pSer935 LRRK2 IC50 of 1.4 nM. |
| PC-21888 |
EB‐42168
G2019S-LRRK2 inhibitor
|
EB‐42168 is a potent, selective G2019S-LRRK2 kinase inhibitor with IC50 of 1.1 nM (pS935-LRRK2) in FRET-based assay, >100-fold selective over WT-LRRR2. |
| PC-21887 |
EB‐42486
G2019S-LRRK2 inhibitor
|
EB‐42486 is a potent, selective G2019S-LRRK2 kinase inhibitor with IC50 of 3.1 nM (pS935-LRRK2) in FRET-based assay, >300-fold selective over WT-LRRR2. |
| PC-21271 |
MK-1468
LRRK2 inhibitor
|
MK-1468 is a potent, selective, brain-penetrant LRRK2 inhibitor with IC50 of 0.4 nM (G2019S LRRK2), potently inhibits the phosphorylation of LRRK2 serine 935 (pSer935) in hPBMCs with IC50 of 2.8 nM. |
| PC-49826 |
Lu AF58786
LRRK2 inhibitor
|
Lu AF58786 is a potent and selective LRRK2 inhibitor with IC50 of 12 nM, 19 nM and 93 nM for LRRK2 WT, LRRK2-G2019S and LRRK2-A2016T in cell-based assays, respectively. |
