G2019S-LRRK2 inhibitor 22

Chemical Structure : G2019S-LRRK2 inhibitor 22

Catalog No.: PC-49302Not For Human Use, Lab Use Only.

G2019S-LRRK2 inhibitor 22 is a novel potent, BBB-penetrant, G2019S-LRRK2 selective kinase inhibitor with IC50 of 4.6 nM, >700-fold selectivity over WT LRRK2.

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Biological Activity

G2019S-LRRK2 inhibitor 22 is a novel potent, BBB-penetrant, G2019S-LRRK2 selective kinase inhibitor with IC50 of 4.6 nM, >700-fold selectivity over WT LRRK2.

Physicochemical Properties

M.Wt	458.528
Formula	C23H24F2N4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-difluoro-4-(5-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)phenyl)-8-thia-2-azaspiro[4.5]decane 8,8-dioxide

References

1. Leśniak RK, et al. Eur J Med Chem. 2022 Aug 24;242:114693.

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