Catalog No.: PC-21271Not For Human Use, Lab Use Only.
MK-1468 is a potent, selective, brain-penetrant LRRK2 inhibitor with IC50 of 0.4 nM (G2019S LRRK2), potently inhibits the phosphorylation of LRRK2 serine 935 (pSer935) in hPBMCs with IC50 of 2.8 nM.
MK-1468 is a potent, selective, brain-penetrant LRRK2 inhibitor with IC50 of 0.4 nM (G2019S LRRK2), potently inhibits the phosphorylation of LRRK2 serine 935 (pSer935) in hPBMCs with IC50 of 2.8 nM.
MK-1468 demonstrates near-equipotent activity for LRRK2 (G2019S) and wild-type LRRK2.
MK-1468 is >100-fold selective against 265 off-target kinases tested, and >1000-fold selectivity against a panel of 117 functional, enzyme, and radioligand binding assays screened (Cerep, Panlabs).
MK-1468 inhibits the phosphorylation of LRRK2 serine 935 (pSer935) in the rat brain, orally active.
