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LRRK2 inhibitor 25

Chemical Structure : LRRK2 inhibitor 25

CAS No.: 2307277-93-4

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LRRK2 inhibitor 25 (LRRK2-IN-7)

Catalog No.: PC-49823Not For Human Use, Lab Use Only.

LRRK2 inhibitor 25 is a potent, selective, CNS-penetrant and ATP competitive LRRK2 inhibitor with biochemical IC50 of 0.9 nM, cellular IC50 of 0.3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LRRK2 inhibitor 25 is a potent, selective, CNS-penetrant and ATP competitive LRRK2 inhibitor with biochemical IC50 of 0.9 nM, cellular IC50 of 0.3 nM.
    LRRK2 inhibitor 25 demonstrated exceptional on-target potency in human peripheral blood mononuclear cells, excellent off-target kinase selectivity, and good brain exposure in rats.

    Physicochemical Properties

    M.Wt 414.51
    Formula C24H26N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-1-(1-(6-((R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)pyrimidin-4-yl)-1H-indazol-6-yl)spiro[2.2]pentane-1-carbonitrile

    References

    1. David A Candito, et al. J Med Chem. 2022 Dec 22;65(24):16801-16817.

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