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Chemical Structure : LRRK2 inhibitor 25
Catalog No.: PC-49823Not For Human Use, Lab Use Only.
LRRK2 inhibitor 25 is a potent, selective, CNS-penetrant and ATP competitive LRRK2 inhibitor with biochemical IC50 of 0.9 nM, cellular IC50 of 0.3 nM.
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LRRK2 inhibitor 25 is a potent, selective, CNS-penetrant and ATP competitive LRRK2 inhibitor with biochemical IC50 of 0.9 nM, cellular IC50 of 0.3 nM.
LRRK2 inhibitor 25 demonstrated exceptional on-target potency in human peripheral blood mononuclear cells, excellent off-target kinase selectivity, and good brain exposure in rats.
| M.Wt | 414.51 | |
| Formula | C24H26N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. David A Candito, et al. J Med Chem. 2022 Dec 22;65(24):16801-16817.
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