Chemical Structure : RN341
CAS No.:
RN341
(RN-341)
Catalog No.: PC-24724Not For Human Use, Lab Use Only.
RN341 is a potent, selective, type II kinase inhibitor of LRRK2 with IC50 of 296 nM, binds to the kinase domain of LRRK2.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RN341 is a potent, selective, type II kinase inhibitor of LRRK2 with IC50 of 296 nM, binds to the kinase domain of LRRK2.
RN341 is highly selective against 96 kinases screened in the DSF assay
RN341 display a strong inhibitory effect on LRRK1 kinase activity.
RN341 inhibits LRRK2RCKW-mediated phosphorylation of Rab8a in vitro with IC50 of 110 nM.
RN341 inhibits phosphorylation of LRRK2 substrate Rabs (such as Rab8a) without affecting the phosphorylation of LRRK2 biomarker site S935.
RN341 inhibits phosphorylation of Rab8a by both the wild-type LRRK2 and mutant kinase G2019S LRRK2.
RN341 rescues kinesin motility in the presence of LRRK2 RCKW in in vitro motility assay.
Physicochemical Properties
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M.Wt
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591.74
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Formula
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C32H33N9OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(3-(tert-butyl)-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(3-(2-(ethylthio)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)urea
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References
1. Raig ND, et al. Sci Adv. 2025 Jun 6;11(23):eadt2050.
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