| Cat. No. |
Product Name |
Information |
| PC-49823 |
LRRK2 inhibitor 25
LRRK2 inhibitor
|
LRRK2 inhibitor 25 is a potent, selective, CNS-penetrant and ATP competitive LRRK2 inhibitor with biochemical IC50 of 0.9 nM, cellular IC50 of 0.3 nM. |
| PC-49822 |
LRRK2 GTP binding inhibitor 68
LRRK2 inhibitor
|
LRRK2 GTP binding inhibitor 68 is a potent, GTP binding inhibitor of LRRK2 with IC90 of 10 nM, inhibits LRRK2 GTP binding and kinase activities. |
| PC-49821 |
FX2149
LRRK2 inhibitor
|
FX2149 (FX 2149) is a potent, BBB permeable inhibitor of LRRK2 GTP binding activity with IC90 of 10 nM, reduces PD-linked mutant LRRK2 variants (G2019S and R1441C) that bound with GTP. |
| PC-49820 |
BIIB122
LRRK2 inhibitor
|
BIIB122 (DNL151) is a potent, selective, CNS-penetrant LRRK2 inhibitor. |
| PC-72161 |
G2019S-LRRK2 inhibitor 38
G2019S-LRRK2 inhibitor
|
G2019S-LRRK2 inhibitor 38 is a potent, selective, brain penetrant G2019S-LRRK2 kinase inhibitor with IC50 of <1 nM, cellular EC50 of 40 nM, >2,000-fold selectivity over WT LRRK2 (cellular EC50>100 uM). |
| PC-72160 |
EB-42486
G2019S-LRRK2 inhibitor
|
EB-42486 (EB42486) is a potent, highly selective G2019S-LRRK2 kinase inhibitor with biochemical IC50 of <0.2 nM. |
| PC-43416 |
GSK2578215A
|
GSK2578215A is a highly potent, selective, BBB-permeable LRRK2 inhibitor with IC50 of 10.9 and 9.9 nM for wild-type LRRK2 and the G2019S mutant, respectively. |
| PC-42945 |
GNE-9605
|
GNE-9605 is a highly potent, selective, brain penetrant LRRK2 inhibitor with Ki of 2 nM, pLRRK2 IC50 of 19 nM. |
| PC-62508 |
PFE-360
|
PFE-360 is a novel potent, selective, brain-penetrating LRRK2 inhibitor with IC50 of 3 nM. |
| PC-62372 |
SR 9444
|
SR 9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK with IC50 of 12 nM and 99 nM respectively. |
| PC-42726 |
LRRK2-IN-1
|
A potent LRRK2 inhibitor with IC50s of 13 nM/6 nM for wild-type/G2019S mutant LRRK2 repectively (0.1 mM ATP in the assay). |
| PC-45094 |
JH-II-127
|
A potent and selective inhibitor of both wild-type and G2019S mutant LRRK2 with IC50 of 6.6 and 2.2 nM, respectively. |
