| Cat. No. |
Product Name |
Information |
| PC-62508 |
PFE-360
LRRK2 inhibitor
|
PFE-360 (PF-06685360) is a potent, selective, brain-penetrating LRRK2 inhibitor with IC50 of 3 nM. |
| PC-62372 |
SR9444
LRRK2/JNK3 inhibitor
|
SR9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK3 with IC50 of 100 nM and 12 nM respectively. |
| PC-42142 |
MLi-2
LRRK2 inhibitor
|
MLi2 is a potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76 nM, cellular IC50 of 1.4 nM (dephosphorylation of LRRK2 pSer935 LRRK2). |
| PC-42726 |
LRRK2-IN-1
LRRK2 inhibitor, PCNA inhibitor
|
LRRK2-IN-1 is a potent LRRK2 inhibitor with IC50s of 13 nM/6 nM for wild-type/G2019S mutant LRRK2 repectively (0.1 mM ATP in the assay), also induces cell cycle arrest and cancer cell death by specifically binding to human proliferating cell nuclear antigen (PCNA) in cancer cells. |
| PC-45094 |
JH-II-127
LRRK2 inhibitor
|
JH-II-127 is a potent and selective inhibitor of both wild-type and G2019S mutant LRRK2 with IC50 of 6.6 and 2.2 nM, respectively. |
| PC-45425 |
GNE-7915 tosylate
LRRK2 inhibitor
|
GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM. |
| PC-45424 |
GNE-7915
LRRK2 inhibitor
|
GNE-7915 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM. |
| PC-22264 |
HG-10-102-01
LRRK2 inhibitor
|
HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and LRRK2 G2019S mutant with IC50 of 20.3 nM and 3.2 nM, respectively. |
| PC-22263 |
CZC-25146
LRRK2 inhibitor
|
CZC-25146 is a potent and selective inhibitor of wild-type LRRK2 and LRRK2 G2019S mutant with IC50 of 4.76 nM and 6.87 nM, respectively. |
| PC-21889 |
MLi-2
LRRK2 inhibitor
|
MLi-2 is a potent, highly selective, orally available, brain-penetrant inhibitor of LRRK2 with IC50 of 0.76 nM, pSer935 LRRK2 IC50 of 1.4 nM. |
| PC-21271 |
MK-1468
LRRK2 inhibitor
|
MK-1468 is a potent, selective, brain-penetrant LRRK2 inhibitor with IC50 of 0.4 nM (G2019S LRRK2), potently inhibits the phosphorylation of LRRK2 serine 935 (pSer935) in hPBMCs with IC50 of 2.8 nM. |
| PC-49820 |
BIIB122
LRRK2 inhibitor
|
BIIB122 (DNL151) is a potent, selective, CNS-penetrant LRRK2 inhibitor. |
